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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1993-11-24
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pubmed:abstractText |
CM-55 is a synthetic analogue of the antibiotic cerulenin with the chemical structure of 2, 3-dodecenyl-4-oxo-dimethyl amide. This compound inhibited the growth of Saccharomyces cerevisiae ATCC 12341 and inhibited protein and lipid synthesis by 91 and 95%, respectively, at a concentration of 50 mug/ml (2.1 x 10(-4) M). The inhibition of protein synthesis was associated with the partial reduction of ribonucleic acid synthesis and leucine transport. The mechanism of inhibition of lipid synthesis was further investigated in a cell-free extract of the yeast. CM-55 inhibited the incorporation of [(14)C]acetyl Coenzyme A (CoA) into both fatty acid (FAF) and non-saponifiable fractions (NSF). However, it did not inhibit [(14)C]malonyl CoA incorporation into FAF and only slightly inhibited [(14)C]mevalonate incorporation into NSF. The activity of 3-hydroxy-3-methylglutaryl CoA (HMG-CoA) synthase was inhibited more strongly than the incorporation of [(14)C]3-hydroxy-3-methylglutaryl CoA into NSF; this could account for the CM-55 inhibition of [(14)C]acetyl CoA incorporation into NSF.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/4157441-13654321,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4157441-14084120,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4157441-4561339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4157441-4587717,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4157441-4597730,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4157441-4598335,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4157441-4625866,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4157441-4628222,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4157441-4858397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4157441-5164097,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4157441-5443164
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0066-4804
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
387-92
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:4157441-Acetates,
pubmed-meshheading:4157441-Acetyl-CoA C-Acetyltransferase,
pubmed-meshheading:4157441-Cerulenin,
pubmed-meshheading:4157441-Fatty Acids,
pubmed-meshheading:4157441-Fatty Acids, Monounsaturated,
pubmed-meshheading:4157441-Hydroxymethylglutaryl-CoA Synthase,
pubmed-meshheading:4157441-Leucine,
pubmed-meshheading:4157441-Lipids,
pubmed-meshheading:4157441-Saccharomyces cerevisiae,
pubmed-meshheading:4157441-Sterols
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pubmed:year |
1974
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pubmed:articleTitle |
Mechanism of action of CM-55, a synthetic analogue of the antilipogenic antibiotic cerulenin.
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pubmed:publicationType |
Journal Article,
Comparative Study
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