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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5930
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pubmed:dateCreated |
1974-12-10
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pubmed:abstractText |
Metiamide, an antagonist of histamine H(2) receptors, was administered intravenously to normal subjects and to patients with a peptic ulcer during vagal stimulation with a constant infusion of insulin. In normal and peptic-ulcer subjects there were reductions of 70% and 71% respectively in gastric-acid output compared with control tests on the same subjects. The decreased acid output resulted from a reduction in both volume of secretion and acid concentration. Metiamide is therefore a potent inhibitor of vagally-induced gastric acid secretion.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0007-1447
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
31
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pubmed:volume |
3
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
554-6
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pubmed:dateRevised |
2010-10-26
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pubmed:meshHeading |
pubmed-meshheading:4153330-Adult,
pubmed-meshheading:4153330-Blood Glucose,
pubmed-meshheading:4153330-Depression, Chemical,
pubmed-meshheading:4153330-Duodenal Ulcer,
pubmed-meshheading:4153330-Female,
pubmed-meshheading:4153330-Gastric Juice,
pubmed-meshheading:4153330-Histamine H1 Antagonists,
pubmed-meshheading:4153330-Humans,
pubmed-meshheading:4153330-Imidazoles,
pubmed-meshheading:4153330-Male,
pubmed-meshheading:4153330-Middle Aged,
pubmed-meshheading:4153330-Receptors, Drug,
pubmed-meshheading:4153330-Secretory Rate,
pubmed-meshheading:4153330-Stomach Ulcer,
pubmed-meshheading:4153330-Sulfides,
pubmed-meshheading:4153330-Thiourea,
pubmed-meshheading:4153330-Vagus Nerve
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pubmed:year |
1974
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pubmed:articleTitle |
Effect of histamine H2-receptor blockade on vagally induced gastric secretion in man.
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pubmed:publicationType |
Journal Article
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