|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
1974-4-5
|
|
pubmed:abstractText |
The effects of tolamolol, propranolol and practolol on both isoprenaline- and exercise-induced tachycardia have been studied in conscious dogs. Tolamolol was approximately equipotent to propranolol and 50 times more potent than practolol in antagonizing exercise-induced tachycardias, but was approximately 12 times less potent than propranolol and 8 times more potent than practolol in blocking isoprenaline-induced tachycardia. It is suggested that antagonism of the tachycardia induced by exercise affords a more meaningful assessment of the possible therapeutic potential of beta-adrenoceptor blocking drugs than does that induced by isoprenaline.
|
|
pubmed:commentsCorrections |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Nov
|
|
pubmed:issn |
0007-1188
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
49
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
560-3
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:4149697-Adrenergic beta-Antagonists,
pubmed-meshheading:4149697-Animals,
pubmed-meshheading:4149697-Benzamides,
pubmed-meshheading:4149697-Cresols,
pubmed-meshheading:4149697-Dogs,
pubmed-meshheading:4149697-Female,
pubmed-meshheading:4149697-Heart Rate,
pubmed-meshheading:4149697-Isoproterenol,
pubmed-meshheading:4149697-Methods,
pubmed-meshheading:4149697-Physical Exertion,
pubmed-meshheading:4149697-Practolol,
pubmed-meshheading:4149697-Propanolamines,
pubmed-meshheading:4149697-Propranolol,
pubmed-meshheading:4149697-Stimulation, Chemical
|
|
pubmed:year |
1973
|
|
pubmed:articleTitle |
Isoprenaline- and exercise- induced tachycardia in the assessment of beta-adrenoceptor blocking drugs; a comparison between tolamolol, practolol and propranolol.
|
|
pubmed:publicationType |
Journal Article,
Comparative Study
|
