Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1974-1-16
pubmed:abstractText
The distribution of integration efficiencies of independent mutations spontaneously occurring in the amiA locus was determined in two strains of pneumococcus. Strain Cl(3) integrates genetic markers with different efficiencies during transformation, whereas strain 401, isogenic with strain Cl(3), does not discriminate between markers and integrates all markers with the same high efficiency. The discriminating strain Cl(3) gives rise to spontaneous mutations in the locus amiA, which fall into four classes with respect to their individual integration efficiencies. Mutations with a low efficiency of integration are equal in number to mutations with a high efficiency. Mutations from the two other classes corresponding to intermediate and very high efficiencies are about five times less frequent. The same four classes were also found among amiA mutants spontaneously occurring in strain 401. However, the two distributions of integration efficiencies of amiA mutants arisen either in strain Cl(3) or strain 401 are significantly different. The number of spontaneous amiA mutants, estimated by two methods, was found to be higher in strain 401 than in strain Cl(3). The increase of the mutation rate in strain 401 could be accounted for by the excess of mutations falling in the two less-efficient classes observed in this strain. The discriminating process which acts during transformation presumably also intervenes in the appearance of spontaneous mutations.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/4148095-14192656, http://linkedlifedata.com/resource/pubmed/commentcorrection/4148095-17247100, http://linkedlifedata.com/resource/pubmed/commentcorrection/4148095-17248131, http://linkedlifedata.com/resource/pubmed/commentcorrection/4148095-17248248, http://linkedlifedata.com/resource/pubmed/commentcorrection/4148095-4379022, http://linkedlifedata.com/resource/pubmed/commentcorrection/4148095-4379828, http://linkedlifedata.com/resource/pubmed/commentcorrection/4148095-4383874, http://linkedlifedata.com/resource/pubmed/commentcorrection/4148095-4389852, http://linkedlifedata.com/resource/pubmed/commentcorrection/4148095-4390084, http://linkedlifedata.com/resource/pubmed/commentcorrection/4148095-4391801, http://linkedlifedata.com/resource/pubmed/commentcorrection/4148095-4400416
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0021-9193
pubmed:author
pubmed:issnType
Print
pubmed:volume
116
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1130-5
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1973
pubmed:articleTitle
Integration efficiencies of spontaneous mutant alleles of amiA locus in pneumococcal transformation.
pubmed:publicationType
Journal Article