| pubmed-article:4139230 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:4139230 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:4139230 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:4139230 | lifeskim:mentions | umls-concept:C0003264 | lld:lifeskim |
| pubmed-article:4139230 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:4139230 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:4139230 | lifeskim:mentions | umls-concept:C0728826 | lld:lifeskim |
| pubmed-article:4139230 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:4139230 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:4139230 | lifeskim:mentions | umls-concept:C0205225 | lld:lifeskim |
| pubmed-article:4139230 | lifeskim:mentions | umls-concept:C0048309 | lld:lifeskim |
| pubmed-article:4139230 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:4139230 | pubmed:dateCreated | 1975-2-18 | lld:pubmed |
| pubmed-article:4139230 | pubmed:abstractText | Our data suggest that fine specificity of antihapten antibodies is a useful Mendelian marker of variable (V) genes. We found that some mouse strains (e.g., C57/BL6) consistently produced heteroclitic anti-(4-hydroxy-3-nitrophenyl)acetyl (NP) antibodies (relative affinity for related (4-hydroxy-5-iodo-3-nitrophenyl)acetyl and (4-hydroxy-3.5-dinitrophenyl)acetyl was always >2) while other strains (e.g., CBA) produced "conventional" anti-NP antibodies (relative affinities were consistently <1). 48 (CBA x C57BL/6)F(1) mice were studied and most of them had heteroclitic anti-NP antibodies. They were backcrossed to the recessive CBA parent, and 87 backcross animals were similarly tested. Those heterozygous for the C57BL/6 heavy (H)-chain allotype were similar to the C57BL/6 and the F(1) mice while mice homozygous for the CBA allotype were indistinguishable from the CBA. Such monogenic inheritance was observed only in the primary response. Predominance of allotype-linked genes in the control of the fine specificity characteristics was confirmed by immunizing selected homozygous mouse strains. These mice contained various mixtures of genes from C57BL, BALB/c, and other strains. Specificity of their anti-NP was exclusively determined by genes linked to the H-chain allotype, no influence could be attributed to other genes including the H-2-linked genes. | lld:pubmed |
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| pubmed-article:4139230 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:4139230 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:4139230 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:4139230 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:4139230 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:4139230 | pubmed:author | pubmed-author:MäkeläOO | lld:pubmed |
| pubmed-article:4139230 | pubmed:author | pubmed-author:ImanishiTT | lld:pubmed |
| pubmed-article:4139230 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:4139230 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:4139230 | pubmed:volume | 140 | lld:pubmed |
| pubmed-article:4139230 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:4139230 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:4139230 | pubmed:pagination | 1498-510 | lld:pubmed |
| pubmed-article:4139230 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:4139230 | pubmed:year | 1974 | lld:pubmed |
| pubmed-article:4139230 | pubmed:articleTitle | Inheritance of antibody specificity. I. Anti-(4-hydroxy-3-nitrophenyl)acetyl of the mouse primary response. | lld:pubmed |
| pubmed-article:4139230 | pubmed:publicationType | Journal Article | lld:pubmed |
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