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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1975-2-18
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pubmed:abstractText |
Our data suggest that fine specificity of antihapten antibodies is a useful Mendelian marker of variable (V) genes. We found that some mouse strains (e.g., C57/BL6) consistently produced heteroclitic anti-(4-hydroxy-3-nitrophenyl)acetyl (NP) antibodies (relative affinity for related (4-hydroxy-5-iodo-3-nitrophenyl)acetyl and (4-hydroxy-3.5-dinitrophenyl)acetyl was always >2) while other strains (e.g., CBA) produced "conventional" anti-NP antibodies (relative affinities were consistently <1). 48 (CBA x C57BL/6)F(1) mice were studied and most of them had heteroclitic anti-NP antibodies. They were backcrossed to the recessive CBA parent, and 87 backcross animals were similarly tested. Those heterozygous for the C57BL/6 heavy (H)-chain allotype were similar to the C57BL/6 and the F(1) mice while mice homozygous for the CBA allotype were indistinguishable from the CBA. Such monogenic inheritance was observed only in the primary response. Predominance of allotype-linked genes in the control of the fine specificity characteristics was confirmed by immunizing selected homozygous mouse strains. These mice contained various mixtures of genes from C57BL, BALB/c, and other strains. Specificity of their anti-NP was exclusively determined by genes linked to the H-chain allotype, no influence could be attributed to other genes including the H-2-linked genes.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/4139230-4114394,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4139230-4117282,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4139230-4119588,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4139230-4120094,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4139230-4120285,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4139230-4131516,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4139230-4142551,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4139230-4194305,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4139230-4389618,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4139230-4544459,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4139230-4586168,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4139230-4672817,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4139230-4781392,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4139230-5023171,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4139230-5083512,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4139230-5279812,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4139230-5444104,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4139230-5558564,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4139230-5939478
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
140
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1498-510
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:4139230-Animals,
pubmed-meshheading:4139230-Antibody Specificity,
pubmed-meshheading:4139230-Chickens,
pubmed-meshheading:4139230-Crosses, Genetic,
pubmed-meshheading:4139230-Epitopes,
pubmed-meshheading:4139230-Genes,
pubmed-meshheading:4139230-Genetic Linkage,
pubmed-meshheading:4139230-Genotype,
pubmed-meshheading:4139230-Globulins,
pubmed-meshheading:4139230-Hemolytic Plaque Technique,
pubmed-meshheading:4139230-Histocompatibility Antigens,
pubmed-meshheading:4139230-Immunization,
pubmed-meshheading:4139230-Immunoglobulin G,
pubmed-meshheading:4139230-Immunoglobulin Heavy Chains,
pubmed-meshheading:4139230-Isoantigens,
pubmed-meshheading:4139230-Mice,
pubmed-meshheading:4139230-Mice, Inbred BALB C,
pubmed-meshheading:4139230-Mice, Inbred C57BL,
pubmed-meshheading:4139230-Mice, Inbred CBA,
pubmed-meshheading:4139230-Nitrobenzenes,
pubmed-meshheading:4139230-Serum Albumin, Bovine,
pubmed-meshheading:4139230-Species Specificity
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pubmed:year |
1974
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pubmed:articleTitle |
Inheritance of antibody specificity. I. Anti-(4-hydroxy-3-nitrophenyl)acetyl of the mouse primary response.
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pubmed:publicationType |
Journal Article
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