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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1974-12-10
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pubmed:abstractText |
In recent studies we have found that GAT not only fails to elicit a GAT-specific response in nonresponder mice but also specifically decreases the ability of nonresponder mice to develop a GAT-specific PFC response to a subsequent challenge with GAT bound to the immunogenic carrier, MBSA. Studies presented in this paper demonstrate that B cells from nonresponder, DBA/1 mice rendered unresponsive by GAT in vivo can respond in vitro to GAT-MBSA if exogenous, carrier-primed T cells are added to the cultures. The unresponsiveness was shown to be the result of impaired carrier-specific helper T-cell function in the spleen cells of GAT-primed mice. Spleen cells from GAT-primed mice specifically suppressed the GAT-specific PFC response of spleen cells from normal DBA/1 mice incubated with GAT-MBSA. This suppression was prevented by pretreatment of GAT-primed spleen cells with anti-theta serum plus C or X irradiation. Identification of the suppressor cells as T cells was confirmed by the demonstration that suppressor cells were confined to the fraction of the column-purified lymphocytes which contained theta-positive cells and a few non-Ig-bearing cells. The significance of these data to our understanding of Ir-gene regulation of the immune response is discussed.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/4137682-4110796,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4137682-4120897,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4137682-4126766,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4137682-4126767,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4137682-4134784,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4137682-4328471,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4137682-4539013,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4137682-4539650,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4137682-4568186,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4137682-4599879,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4137682-4599880,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4137682-4750862,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4137682-4857865,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4137682-4934502,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4137682-6034749
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
140
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
648-59
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pubmed:dateRevised |
2010-6-22
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pubmed:meshHeading |
pubmed-meshheading:4137682-Alanine,
pubmed-meshheading:4137682-Animals,
pubmed-meshheading:4137682-Antigens,
pubmed-meshheading:4137682-B-Lymphocytes,
pubmed-meshheading:4137682-Cell Separation,
pubmed-meshheading:4137682-Dextrans,
pubmed-meshheading:4137682-Epitopes,
pubmed-meshheading:4137682-Erythrocytes,
pubmed-meshheading:4137682-Genotype,
pubmed-meshheading:4137682-Glutamates,
pubmed-meshheading:4137682-Immune Tolerance,
pubmed-meshheading:4137682-Immunity, Cellular,
pubmed-meshheading:4137682-Immunization,
pubmed-meshheading:4137682-Immunoglobulin Fab Fragments,
pubmed-meshheading:4137682-Mice,
pubmed-meshheading:4137682-Mice, Inbred DBA,
pubmed-meshheading:4137682-Pertussis Vaccine,
pubmed-meshheading:4137682-Radiation Effects,
pubmed-meshheading:4137682-Sheep,
pubmed-meshheading:4137682-T-Lymphocytes,
pubmed-meshheading:4137682-Tyrosine
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pubmed:year |
1974
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pubmed:articleTitle |
Genetic control of immune responses in vitro. V. Stimulation of suppressor T cells in nonresponder mice by the terpolymer L-glutamic acid 60-L-alanine 30-L-tyrosine 10 (GAT).
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pubmed:publicationType |
Journal Article
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