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rdf:type |
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lifeskim:mentions |
umls-concept:C0024109,
umls-concept:C0030685,
umls-concept:C0033554,
umls-concept:C0034489,
umls-concept:C0205263,
umls-concept:C0220806,
umls-concept:C0391871,
umls-concept:C0680255,
umls-concept:C0999699,
umls-concept:C1283071,
umls-concept:C1285354,
umls-concept:C1963578
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pubmed:issue |
2
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pubmed:dateCreated |
1974-9-17
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pubmed:abstractText |
1. Rabbit aorta contracting substance (RCS) and prostaglandins were released from guinea-pig isolated perfused lungs by gentle massage and also by infusion of Prosparol.2. RCS and prostaglandins were also released by infusion into the pulmonary artery of bradykinin, arachidonic and dihomo-gamma-linolenic acids or shock perfusate (containing RCS-releasing factor).3. Arachidonic and dihomo-gamma-linolenic acids caused a prolonged release of RCS and prostaglandins whereas bradykinin and shock perfusate gave a short-lasting output.4. RCS and prostaglandins, together with histamine were released when superfused chopped lung tissue was agitated.5. Challenge of sensitized guinea-pigs in vivo led to the release of an RCS-like substance into the carotid arterial blood.6. Intravenous injection of bradykinin into guinea-pigs also released an RCS-like substance.7. The release of RCS and prostaglandins was inhibited by aspirin or indomethacin in all experiments.8. RCS contracted all vascular tissues investigated and also rat stomach strip.9. The half-life of RCS was estimated as 1-2 minutes.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/4135341-13694701,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4135341-13883159,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4135341-14173316,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4135341-14228136,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4135341-4106477,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4135341-4382230,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4135341-4388134,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4135341-4389381,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4135341-4389382,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4135341-4400351,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4135341-4402307,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4135341-4686554,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4135341-4983971,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4135341-4997426,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4135341-5041506,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4135341-5158211,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4135341-5284360,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4135341-5284361,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4135341-5284362,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4135341-5476751,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4135341-5497810,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4135341-5497833,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4135341-6074965
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0007-1188
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
49
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
226-42
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:4135341-Angiotensin II,
pubmed-meshheading:4135341-Animals,
pubmed-meshheading:4135341-Aorta,
pubmed-meshheading:4135341-Arachidonic Acids,
pubmed-meshheading:4135341-Arachis hypogaea,
pubmed-meshheading:4135341-Aspirin,
pubmed-meshheading:4135341-Bradykinin,
pubmed-meshheading:4135341-Guinea Pigs,
pubmed-meshheading:4135341-Half-Life,
pubmed-meshheading:4135341-Histamine Release,
pubmed-meshheading:4135341-Indomethacin,
pubmed-meshheading:4135341-Injections, Intra-Arterial,
pubmed-meshheading:4135341-Linolenic Acids,
pubmed-meshheading:4135341-Lung,
pubmed-meshheading:4135341-Male,
pubmed-meshheading:4135341-Muscle Contraction,
pubmed-meshheading:4135341-Oils,
pubmed-meshheading:4135341-Ovalbumin,
pubmed-meshheading:4135341-Particle Size,
pubmed-meshheading:4135341-Prostaglandins,
pubmed-meshheading:4135341-Rabbits,
pubmed-meshheading:4135341-Rats,
pubmed-meshheading:4135341-Vasoconstrictor Agents
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pubmed:year |
1973
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pubmed:articleTitle |
Release of rabbit aorta contracting substance (RCS) and prostaglandins induced by chemical or mechanical stimulation of guinea-pig lungs.
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pubmed:publicationType |
Journal Article,
In Vitro
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