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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1974-7-20
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pubmed:abstractText |
Bleomycin inhibits cell division in HeLa S-3 and other mammalian epithelial cell lines. Its effect on suspension cultured cells is far greater than on monolayer cells; this was found to be due partly to the absence of divalent ions. Other mammalian epithelial lines in suspension culture are very sensitive but fibroblastic cells (BHK 21/C13/DWS-3) grown under identical conditions are relatively insensitive. This study has established that bleomycin is a powerful anti-mitotic agent during the G(2) phase but it does not prevent prophase cells from completing a normal mitotic division. Its ability to suppress DNA synthesis contributes little to the inhibition of cell cycling.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/4133781-13297784,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4133781-13563465,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4133781-13936488,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4133781-13984808,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4133781-13991748,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4133781-14367363,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4133781-4108197,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4133781-4112751,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4133781-4119484,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4133781-4881244,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4133781-4975612,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4133781-4982665,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4133781-5350467,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4133781-5466337,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4133781-5529244,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4133781-5630770,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4133781-5668429,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4133781-5752103,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4133781-5815687,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4133781-5822479,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4133781-5903174,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4133781-5953301,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4133781-6072277,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4133781-6082280
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0007-0920
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
29
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
117-31
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pubmed:dateRevised |
2011-7-20
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pubmed:meshHeading |
pubmed-meshheading:4133781-Animals,
pubmed-meshheading:4133781-Bleomycin,
pubmed-meshheading:4133781-Carbon Radioisotopes,
pubmed-meshheading:4133781-Cell Count,
pubmed-meshheading:4133781-Cell Division,
pubmed-meshheading:4133781-Cell Line,
pubmed-meshheading:4133781-Clone Cells,
pubmed-meshheading:4133781-Cricetinae,
pubmed-meshheading:4133781-Cytidine,
pubmed-meshheading:4133781-DNA,
pubmed-meshheading:4133781-HeLa Cells,
pubmed-meshheading:4133781-Humans,
pubmed-meshheading:4133781-Kidney,
pubmed-meshheading:4133781-Mitosis,
pubmed-meshheading:4133781-Protein Biosynthesis,
pubmed-meshheading:4133781-RNA,
pubmed-meshheading:4133781-Thymidine,
pubmed-meshheading:4133781-Time Factors,
pubmed-meshheading:4133781-Tritium,
pubmed-meshheading:4133781-Uridine
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pubmed:year |
1974
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pubmed:articleTitle |
Anti-mitotic activity of bleomycin: time of action in the mammalian cell cycle.
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pubmed:publicationType |
Journal Article
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