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rdf:type |
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lifeskim:mentions |
umls-concept:C0003261,
umls-concept:C0018593,
umls-concept:C0085732,
umls-concept:C0086574,
umls-concept:C0301872,
umls-concept:C0591833,
umls-concept:C1510827,
umls-concept:C1515655,
umls-concept:C1515877,
umls-concept:C1522485,
umls-concept:C1701203,
umls-concept:C1708632,
umls-concept:C1879547,
umls-concept:C1948023
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pubmed:issue |
4
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pubmed:dateCreated |
1974-5-7
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|
pubmed:abstractText |
The ability of meta-nitrobenzenediazonium fluoborate (m-NBDF)-labeled thymus and spleen (S) cells to transfer immunity to 2,4-dinitrophenyl (DNP) into irradiated syngeneic recipients was investigated. There was a significant increase in the number of anti-DNP plaque-forming cells (PFC) when m-NBDF-labeled thymus cells and normal spleen cells, or normal thymus cells and m-NBDF-labeled spleen cells were transferred, but not when both thymus- and S-cell populations were labeled and injected together into irradiated recipients. The ability of these cell populations to cooperate and enhance the in vivo immune response to DNP is discussed. The T cells seem to be actively involved in the development of this response; they participate beyond the mere role of carrying and presenting antigen to the B cells. It is suggested that cell to cell contact between T and B cells may be an important factor in the elicitation of an immune response. In addition, the cellular interaction is affected by irradiating the thymus cell preparation and the initiating interaction required for antibody synthesis probably occurs within 48 h after injecting the cell populations into the syngeneic irradiated recipients.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/4131514-13936948,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4131514-14029139,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4131514-14097352,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4131514-14134310,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4131514-14203195,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4131514-14284950,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4131514-4103886,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4131514-4106095,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4131514-4112926,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4131514-4117528,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4131514-4119248,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4131514-4119592,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4131514-4119933,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4131514-4144030,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4131514-4170425,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4131514-4174545,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4131514-4177521,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4131514-4194660,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4131514-4196067,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4131514-4399419,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4131514-4539678,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4131514-4540732,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4131514-4569167,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4131514-4674386,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4131514-4920186,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4131514-4927671,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4131514-4945477,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4131514-4950444,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4131514-5061980,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4131514-5157966,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4131514-5165203,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4131514-5347625,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4131514-5409977,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4131514-5809514,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4131514-5919593,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4131514-6025570,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4131514-6034749
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0022-1007
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
139
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
943-56
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:4131514-Animals,
pubmed-meshheading:4131514-Antibody Formation,
pubmed-meshheading:4131514-Antibody-Producing Cells,
pubmed-meshheading:4131514-B-Lymphocytes,
pubmed-meshheading:4131514-Binding Sites, Antibody,
pubmed-meshheading:4131514-Diazonium Compounds,
pubmed-meshheading:4131514-Epitopes,
pubmed-meshheading:4131514-Female,
pubmed-meshheading:4131514-Haptens,
pubmed-meshheading:4131514-Hemolytic Plaque Technique,
pubmed-meshheading:4131514-Immune Sera,
pubmed-meshheading:4131514-Immunity, Maternally-Acquired,
pubmed-meshheading:4131514-Mice,
pubmed-meshheading:4131514-Nitrobenzenes,
pubmed-meshheading:4131514-Radiation Chimera,
pubmed-meshheading:4131514-T-Lymphocytes,
pubmed-meshheading:4131514-Transplantation, Homologous
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pubmed:year |
1974
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pubmed:articleTitle |
Stimulation of antibody production to the hapten 2,4-dinitrobenzene by affinity labeled murine lymphoid cells. I. Ability of affinity labeled murine lymphoid cells to activate the in vivo immune response.
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pubmed:publicationType |
Journal Article
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