|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0004096,
umls-concept:C0012694,
umls-concept:C0026336,
umls-concept:C0026447,
umls-concept:C0030131,
umls-concept:C0030625,
umls-concept:C0034330,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0078944,
umls-concept:C0149576,
umls-concept:C0205198,
umls-concept:C0220723,
umls-concept:C0282555,
umls-concept:C0429865,
umls-concept:C1280500,
umls-concept:C1549860,
umls-concept:C1705241,
umls-concept:C1705242,
umls-concept:C1707455,
umls-concept:C2242460
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|
pubmed:issue |
1-6
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|
pubmed:dateCreated |
1978-2-23
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|
pubmed:abstractText |
DSCG and PRD-92-Ea showed tachyphylaxis in the rat PCA test when a large intravenous dose (40 mg/kg of DSCG and 20 mg/kg of PRD-92-Ea) was given 30 min before administering intravenously the expected effective doses at the time of antigen challenge. This predosing led to a marked loss of effectiveness. Cross-reacting tachyphylaxis was also demonstrated in this model. Predosing rats with DSCG led to a great loss of effectiveness of a subsequent expected active dose of PRD-92-Ea and predosing with PRD-92-Ea had the same effect in preventing the antiallergic action of a subsequent dose of DSCG. The Rhesus monkey (Macaca mulatta) did not exhibit this phenomenon of tachyphylaxis. PRD-92-Ea and DSCG were given intravenously 30 min before and the same dose of 20 mg/kg repeated just before Ascaris suum challenge in the Rhesus monkey asthma model with no loss of their expected effectiveness.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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|
pubmed:issn |
0020-5915
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
55
|
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pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
343-9
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pubmed:dateRevised |
2009-10-27
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pubmed:meshHeading |
pubmed-meshheading:412794-Administration, Oral,
pubmed-meshheading:412794-Animals,
pubmed-meshheading:412794-Asthma,
pubmed-meshheading:412794-Benzopyrans,
pubmed-meshheading:412794-Cromolyn Sodium,
pubmed-meshheading:412794-Cross Reactions,
pubmed-meshheading:412794-Disease Models, Animal,
pubmed-meshheading:412794-Dose-Response Relationship, Immunologic,
pubmed-meshheading:412794-Haplorhini,
pubmed-meshheading:412794-Injections, Intravenous,
pubmed-meshheading:412794-Macaca mulatta,
pubmed-meshheading:412794-Male,
pubmed-meshheading:412794-Passive Cutaneous Anaphylaxis,
pubmed-meshheading:412794-Rats,
pubmed-meshheading:412794-Tachyphylaxis,
pubmed-meshheading:412794-Time Factors
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pubmed:year |
1977
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pubmed:articleTitle |
The difference in effect of predosing with antiallergic compounds between the rat PCA model and the monkey asthma model. Comparison of the effects of PRD-92-Ea and disodium cromoglycate.
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pubmed:publicationType |
Journal Article,
Comparative Study
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