Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1973-9-12
pubmed:abstractText
The immunogenicity of single, private H-2 specificities has been tested. In most cases, the specificity was known to be confined either to H-2K or to H-2D. This was accomplished by the appropriate choice, as donor and recipient, or parent of the F(1) hybrid recipient, of congenic strains differing at H-2 only, and of recombinant haplotypes in donor and/or recipient. By nearly all tests, the H-2K antigen appeared to be a stronger immunogen than the H-2D antigen. Skin grafts with an H-2K difference showed median survival times (MST) of 9.3-14.5 days; for H-2D the values were 13.8-18.6. The difference was also present, though narrowed, for second-set grafts. H-2K grafts regularly engendered a demonstrable cytotoxic antibody response; with H-2D differences the response was absent or very weak. K end cytotoxic titers after multiple immunizations with lymphoid tissues ranged from 1/32 to 1/2,048, D end titers from 0 to 1/128. Hemagglutination titers showed no clear difference. The results of passive enhancement of skin grafts with H-2 alloantibody produced in donor recipient combinations, identical to those used for the skin grafts showed a different pattern. H-2K, despite its greater immunogenic strength was more easily enhanced than H-2D. Prolongation of MST's for H-2K was 2.4-6.7 days, for H-2D grafts, 0.2-1.5 days.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/4123828-13233807, http://linkedlifedata.com/resource/pubmed/commentcorrection/4123828-13355191, http://linkedlifedata.com/resource/pubmed/commentcorrection/4123828-13599016, http://linkedlifedata.com/resource/pubmed/commentcorrection/4123828-14245787, http://linkedlifedata.com/resource/pubmed/commentcorrection/4123828-14284925, http://linkedlifedata.com/resource/pubmed/commentcorrection/4123828-14326057, http://linkedlifedata.com/resource/pubmed/commentcorrection/4123828-4106305, http://linkedlifedata.com/resource/pubmed/commentcorrection/4123828-4106314, http://linkedlifedata.com/resource/pubmed/commentcorrection/4123828-4106335, http://linkedlifedata.com/resource/pubmed/commentcorrection/4123828-4108876, http://linkedlifedata.com/resource/pubmed/commentcorrection/4123828-4110980, http://linkedlifedata.com/resource/pubmed/commentcorrection/4123828-4112414, http://linkedlifedata.com/resource/pubmed/commentcorrection/4123828-4112417, http://linkedlifedata.com/resource/pubmed/commentcorrection/4123828-4121181, http://linkedlifedata.com/resource/pubmed/commentcorrection/4123828-4266664, http://linkedlifedata.com/resource/pubmed/commentcorrection/4123828-4400221, http://linkedlifedata.com/resource/pubmed/commentcorrection/4123828-4404878, http://linkedlifedata.com/resource/pubmed/commentcorrection/4123828-4515607, http://linkedlifedata.com/resource/pubmed/commentcorrection/4123828-4550992, http://linkedlifedata.com/resource/pubmed/commentcorrection/4123828-4552366, http://linkedlifedata.com/resource/pubmed/commentcorrection/4123828-4554451, http://linkedlifedata.com/resource/pubmed/commentcorrection/4123828-4572133, http://linkedlifedata.com/resource/pubmed/commentcorrection/4123828-4572155, http://linkedlifedata.com/resource/pubmed/commentcorrection/4123828-4586480, http://linkedlifedata.com/resource/pubmed/commentcorrection/4123828-4626039, http://linkedlifedata.com/resource/pubmed/commentcorrection/4123828-4931454, http://linkedlifedata.com/resource/pubmed/commentcorrection/4123828-5034148, http://linkedlifedata.com/resource/pubmed/commentcorrection/4123828-5050615, http://linkedlifedata.com/resource/pubmed/commentcorrection/4123828-5138477, http://linkedlifedata.com/resource/pubmed/commentcorrection/4123828-5338633, http://linkedlifedata.com/resource/pubmed/commentcorrection/4123828-5558558, http://linkedlifedata.com/resource/pubmed/commentcorrection/4123828-5558560, http://linkedlifedata.com/resource/pubmed/commentcorrection/4123828-5849237, http://linkedlifedata.com/resource/pubmed/commentcorrection/4123828-5931919
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0022-1007
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
138
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
259-77
pubmed:dateRevised
2010-6-22
pubmed:meshHeading
pubmed-meshheading:4123828-Animals, pubmed-meshheading:4123828-Antibody Formation, pubmed-meshheading:4123828-Crossing Over, Genetic, pubmed-meshheading:4123828-Cytotoxicity Tests, Immunologic, pubmed-meshheading:4123828-Epitopes, pubmed-meshheading:4123828-Female, pubmed-meshheading:4123828-Graft Rejection, pubmed-meshheading:4123828-Hemagglutination Tests, pubmed-meshheading:4123828-Histocompatibility, pubmed-meshheading:4123828-Histocompatibility Antigens, pubmed-meshheading:4123828-Immune Sera, pubmed-meshheading:4123828-Immunization, Passive, pubmed-meshheading:4123828-Injections, Intraperitoneal, pubmed-meshheading:4123828-Isoantibodies, pubmed-meshheading:4123828-Male, pubmed-meshheading:4123828-Mice, pubmed-meshheading:4123828-Mice, Inbred Strains, pubmed-meshheading:4123828-Skin Transplantation, pubmed-meshheading:4123828-Transplantation, Homologous, pubmed-meshheading:4123828-Transplantation Immunology
pubmed:year
1973
pubmed:articleTitle
Comparative immunogenicity and enhanceability of individual H-2K and H-2D specificities of the murine histocompatibility-2 complex.
pubmed:publicationType
Journal Article