Linked Life Data

412241

Source:http://linkedlifedata.com/resource/pubmed/id/412241

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1978-1-27
pubmed:abstractText
Fresh erythrocytes from unanesthetized beagles, rhesus monkeys, rabbits and mice have increased susceptibility to hypotonic lysis after incubation for 30 minutes with high concentrations of daunorubicin. The effect is biphasic in that lower concentrations of drug decrease lytic susceptibility. EDTA diminishes the susceptibility of cells to lysis after treatment with the drug. Red cells from humans and from Sprague-Dawley rats may show either increased or decreased susceptibility to hypotonic lysis; these diverse reactions are proportional to relative fragility and reflect individual variation in the case of human cells and possibly other factors in animal cells. The species-specific and individualistic hemolytic responses suggest possible membrane sites of action for this class of drugs.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0034-5164
pubmed:author
pubmed:issnType
Print
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
519-31
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1977
pubmed:articleTitle
Membrane actions of daunorubicin in mammalian erythrocytes.
pubmed:publicationType
Journal Article, In Vitro