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pubmed:otherAbstract |
PIP: 267 fertile women less than 40 years old took .5 mg of chlormadinone daily for a total of 3199 months to assess its effectiveness as an oral contraceptive. The total pregnancy rate, calculated by the Pearl Formula, was 4.5 pregnancies per 100 women years and the rate for method failure was 3.7 pregnancies per women years. The rates calculated by the life-table method were 2.5 pregnancies per 100 women for the first year and 4.1 pregnancies per 100 women for the first 24 months. All births were normal. Other disadvantages were abnormal and irregular bleeding, experienced by 107 women including 40% of all patients with histories of regular menses. Side effects other than abnormal bleeding were infrequent, with headaches as the most common (7.9%). Chlormadinone acetate was not recommended for contraceptive use at this time due to a high pregnancy rate and abnormal bleeding.
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