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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1978-1-27
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pubmed:abstractText |
The development of IgG L-glutamic Acid60-L-alanine30-L-tyrosine10 (GAT)-specific plaque-forming cell responses in vitro by virgin and immune (responder X nonresponder)F1 spleen cells after stimulation with responder and nonresponder parental GAT-macrophages (Mphi) was investigated. Virgin F1 spleen cells developed comparable primary responses to both parental GAT-Mphi. By contrast, F1 spleen cells from mice immunized with GAT or responder parental GAT-Mphi developed secondary responses after stimulation with only responder parental GAT-Mphi. Spleen cells from F1 mice immunized with nonresponder parental GAT-Mphi developed secondary responses to these GAT-Mphi, but failed to respond to responder parental GAT-Mphi. These results are discussed in the context of genetic restrictions regulating Mphi-T-cell interactions in secondary antibody responses and the possible expression of Ir-gene function in Mphi.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/411879-1079849,
http://linkedlifedata.com/resource/pubmed/commentcorrection/411879-1080181,
http://linkedlifedata.com/resource/pubmed/commentcorrection/411879-1084997,
http://linkedlifedata.com/resource/pubmed/commentcorrection/411879-233906,
http://linkedlifedata.com/resource/pubmed/commentcorrection/411879-301177,
http://linkedlifedata.com/resource/pubmed/commentcorrection/411879-302177,
http://linkedlifedata.com/resource/pubmed/commentcorrection/411879-4126766,
http://linkedlifedata.com/resource/pubmed/commentcorrection/411879-4126767,
http://linkedlifedata.com/resource/pubmed/commentcorrection/411879-4126770,
http://linkedlifedata.com/resource/pubmed/commentcorrection/411879-4137682,
http://linkedlifedata.com/resource/pubmed/commentcorrection/411879-4262958,
http://linkedlifedata.com/resource/pubmed/commentcorrection/411879-4542806,
http://linkedlifedata.com/resource/pubmed/commentcorrection/411879-61102,
http://linkedlifedata.com/resource/pubmed/commentcorrection/411879-68474,
http://linkedlifedata.com/resource/pubmed/commentcorrection/411879-70497,
http://linkedlifedata.com/resource/pubmed/commentcorrection/411879-956724
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0022-1007
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
146
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1827-32
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1977
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pubmed:articleTitle |
Secondary antibody responses in vitro to L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT) by (responder X nonresponder)F1 spleen cells stimulated by parental GAT-macrophages.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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