| pubmed-article:4115131 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:4115131 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:4115131 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:4115131 | lifeskim:mentions | umls-concept:C0560175 | lld:lifeskim |
| pubmed-article:4115131 | lifeskim:mentions | umls-concept:C0017007 | lld:lifeskim |
| pubmed-article:4115131 | lifeskim:mentions | umls-concept:C0018593 | lld:lifeskim |
| pubmed-article:4115131 | lifeskim:mentions | umls-concept:C0020964 | lld:lifeskim |
| pubmed-article:4115131 | lifeskim:mentions | umls-concept:C1704410 | lld:lifeskim |
| pubmed-article:4115131 | lifeskim:mentions | umls-concept:C1825351 | lld:lifeskim |
| pubmed-article:4115131 | lifeskim:mentions | umls-concept:C1824986 | lld:lifeskim |
| pubmed-article:4115131 | lifeskim:mentions | umls-concept:C2829592 | lld:lifeskim |
| pubmed-article:4115131 | lifeskim:mentions | umls-concept:C1948027 | lld:lifeskim |
| pubmed-article:4115131 | lifeskim:mentions | umls-concept:C1706209 | lld:lifeskim |
| pubmed-article:4115131 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:4115131 | pubmed:dateCreated | 1972-10-2 | lld:pubmed |
| pubmed-article:4115131 | pubmed:abstractText | A hapten, 4-hydroxy-3-iodo-5-nitrophenylacetic acid (NIP) when coupled to isologous mouse gamma globulin (MgammaG) elicits a hapten-specific immune response in mice if administered in Freund's complete adjuvant. This response is measurable by the capacity of the sera to bind N(125)IP, by detection of NIP-specific plaque-forming cells (B cells), and by in vitro secondary type antigen-driven DNA synthesis (T cells and probably B cells). The in vitro response requires both the hapten and carrier since neither by itself is capable of stimulating the spleen cells. This same antigen gives rise to hapten-specific tolerance when given in the soluble form. Mice pretreated with soluble NIP-MgammaG and challenged with NIP coupled to a heterologous carrier give a normal antibody response to the carrier but have barely detectable levels of antibody to NIP. Spleen cells from mice made tolerant to NIP-MgammaG do not respond in vitro with increased DNA synthesis. This implies that thymus-derived cells as well as bone marrow-derived cells are involved in hapten-specific tolerance. | lld:pubmed |
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| pubmed-article:4115131 | pubmed:language | eng | lld:pubmed |
| pubmed-article:4115131 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:4115131 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:4115131 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:4115131 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:4115131 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:4115131 | pubmed:author | pubmed-author:MoorheadJ WJW | lld:pubmed |
| pubmed-article:4115131 | pubmed:author | pubmed-author:ClamanH NHN | lld:pubmed |
| pubmed-article:4115131 | pubmed:author | pubmed-author:WaltersC SCS | lld:pubmed |
| pubmed-article:4115131 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:4115131 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:4115131 | pubmed:volume | 136 | lld:pubmed |
| pubmed-article:4115131 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:4115131 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:4115131 | pubmed:pagination | 546-55 | lld:pubmed |
| pubmed-article:4115131 | pubmed:dateRevised | 2010-6-22 | lld:pubmed |
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| pubmed-article:4115131 | pubmed:year | 1972 | lld:pubmed |
| pubmed-article:4115131 | pubmed:articleTitle | Immunity tolerance to a hapten (NIP) coupled to an isologous carrier (mouse gamma globulin). | lld:pubmed |
| pubmed-article:4115131 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:4115131 | pubmed:publicationType | In Vitro | lld:pubmed |
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