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rdf:type |
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lifeskim:mentions |
umls-concept:C0017007,
umls-concept:C0018593,
umls-concept:C0020964,
umls-concept:C0025914,
umls-concept:C0026809,
umls-concept:C0560175,
umls-concept:C1704410,
umls-concept:C1706209,
umls-concept:C1824986,
umls-concept:C1825351,
umls-concept:C1948027,
umls-concept:C2829592
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pubmed:issue |
3
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pubmed:dateCreated |
1972-10-2
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pubmed:abstractText |
A hapten, 4-hydroxy-3-iodo-5-nitrophenylacetic acid (NIP) when coupled to isologous mouse gamma globulin (MgammaG) elicits a hapten-specific immune response in mice if administered in Freund's complete adjuvant. This response is measurable by the capacity of the sera to bind N(125)IP, by detection of NIP-specific plaque-forming cells (B cells), and by in vitro secondary type antigen-driven DNA synthesis (T cells and probably B cells). The in vitro response requires both the hapten and carrier since neither by itself is capable of stimulating the spleen cells. This same antigen gives rise to hapten-specific tolerance when given in the soluble form. Mice pretreated with soluble NIP-MgammaG and challenged with NIP coupled to a heterologous carrier give a normal antibody response to the carrier but have barely detectable levels of antibody to NIP. Spleen cells from mice made tolerant to NIP-MgammaG do not respond in vitro with increased DNA synthesis. This implies that thymus-derived cells as well as bone marrow-derived cells are involved in hapten-specific tolerance.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/4115131-14113075,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4115131-14113076,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4115131-14265884,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4115131-4101345,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4115131-4109111,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4115131-4192271,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4115131-4195526,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4115131-4397662,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4115131-4938448,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4115131-4941003,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4115131-5461775,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4115131-5770387,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4115131-5939478
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
136
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
546-55
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pubmed:dateRevised |
2010-6-22
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pubmed:meshHeading |
pubmed-meshheading:4115131-Animals,
pubmed-meshheading:4115131-Antibody Specificity,
pubmed-meshheading:4115131-Antibody-Producing Cells,
pubmed-meshheading:4115131-Bone Marrow,
pubmed-meshheading:4115131-Bone Marrow Cells,
pubmed-meshheading:4115131-DNA,
pubmed-meshheading:4115131-Freund's Adjuvant,
pubmed-meshheading:4115131-Haptens,
pubmed-meshheading:4115131-Immune Tolerance,
pubmed-meshheading:4115131-Immunity,
pubmed-meshheading:4115131-Immunoglobulin G,
pubmed-meshheading:4115131-Mice,
pubmed-meshheading:4115131-Mice, Inbred Strains,
pubmed-meshheading:4115131-Phenylacetates,
pubmed-meshheading:4115131-Spleen,
pubmed-meshheading:4115131-Thymidine,
pubmed-meshheading:4115131-Thymus Gland,
pubmed-meshheading:4115131-Tritium,
pubmed-meshheading:4115131-gamma-Globulins
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pubmed:year |
1972
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pubmed:articleTitle |
Immunity tolerance to a hapten (NIP) coupled to an isologous carrier (mouse gamma globulin).
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pubmed:publicationType |
Journal Article,
In Vitro
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