|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0003241,
umls-concept:C0003261,
umls-concept:C0018134,
umls-concept:C0175668,
umls-concept:C0220781,
umls-concept:C0234112,
umls-concept:C0542341,
umls-concept:C0560175,
umls-concept:C1706209,
umls-concept:C1883254,
umls-concept:C1948023
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
1972-3-17
|
|
pubmed:abstractText |
The studies reported here demonstrate that immunocompetent lymphoid cells from allogeneic donor guinea pigs stimulate the synthesis of anti-DNP and anti-OVA antibodies by recipients previously primed with DNP-OVA. This allogeneic effect occurs spontaneously in the absence of any further anti-genic challenge. Furthermore, the transfer of allogeneic cells prepares DNP-OVA-primed recipients for a striking secondary anti-DNP response to DNP-BGG; this occurs in equal degree whether or not the cells are derived from BGG-primed donors. We suggest that the allogeneic cells function by virtue of a specific immunologic attack of grafted cells on host cells. This conclusion is made on the basis of the following evidence: (a) The failure of observing the phenomenon with L(2)C leukemia cells and irradiated strain 2 lymph node and spleen cells which, although capable of initiating a host-versus-graft response, are incapable of mediating graft-versus-host reactions; and (b) the inability of (strain 2 x strain 13) F(1) hybrids to mediate the allogeneic effect in strain 13 recipients. The analysis of this phenomenon may offer a key to the delineation of mechanisms involved in the activation of precursors of antibody-forming cells.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/4109111-13138713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4109111-13834506,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4109111-14076917,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4109111-4101344,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4109111-4101345,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4109111-4110123,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4109111-4181830,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4109111-4192271,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4109111-4196067,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4109111-4383410,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4109111-4391693,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4109111-4392946,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4109111-4927594,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4109111-4945475,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4109111-4945476,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4109111-4945477,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4109111-4979775,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4109111-6023661
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
0022-1007
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
1
|
|
pubmed:volume |
133
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
169-86
|
|
pubmed:dateRevised |
2010-6-22
|
|
pubmed:meshHeading |
pubmed-meshheading:4109111-Animals,
pubmed-meshheading:4109111-Antibody Formation,
pubmed-meshheading:4109111-Antibody Specificity,
pubmed-meshheading:4109111-Antibody-Producing Cells,
pubmed-meshheading:4109111-Carrier State,
pubmed-meshheading:4109111-Dinitrophenols,
pubmed-meshheading:4109111-Graft vs Host Reaction,
pubmed-meshheading:4109111-Guinea Pigs,
pubmed-meshheading:4109111-Haptens,
pubmed-meshheading:4109111-Lymph Nodes,
pubmed-meshheading:4109111-Lymphocytes,
pubmed-meshheading:4109111-Ovalbumin,
pubmed-meshheading:4109111-Spleen,
pubmed-meshheading:4109111-gamma-Globulins
|
|
pubmed:year |
1971
|
|
pubmed:articleTitle |
Carrier function in anti-hapten antibody responses. 3. Stimulation of antibody synthesis and facilitation of hapten-specific secondary antibody responses by graft-versus-host reactions.
|
|
pubmed:publicationType |
Journal Article
|
