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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1972-2-21
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pubmed:abstractText |
1. Antisera have been produced in rabbits to benzylpenicillin and four members of the cephalosporin C family and to conjugates of these substances with bovine gamma-globulin. 2. Deacetoxycephalosporin C reacted less readily and deacetylcephalosporin C lactone more readily with bovine gamma-globulin than did benzylpenicillin, cephalosporin C or deacetylcephalosporin C. 3. Antisera to free or conjugated benzylpenicillin agglutinated red cells sensitized with a variety of penicillins, but only reacted to a significant extent with cells sensitized with the cephalosporins tested when the latter contained an N-phenylacetyl or chemically related side chain. 4. Antisera to members of the cephalosporin C family agglutinated cells sensitized with these cephalosporins or with penicillin N, but did not react with cephalosporins whose side chains were chemically unrelated to alpha-aminoadipic acid. 5. Members of the cephalosporin C family and products of hydrolysis of cephalosporin C behaved as hapten inhibitors of antisera to cephalosporin C, but 7-aminocephalosporanic acid was relatively ineffective. 6. These findings are discussed in relation to differences in the chemical properties of penicillins and cephalosporins.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/4108368-13198858,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4108368-13208584,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4108368-13376900,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4108368-13555856,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4108368-13681080,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4108368-13960249,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4108368-14028302,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4108368-14063394,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4108368-14197330,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4108368-14296289,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4108368-14464604,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4108368-14483914,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4108368-4160334,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4108368-4169033,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4108368-5435685,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4108368-5435686,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4108368-5657240,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4108368-5773314,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4108368-5862414,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4108368-5924995,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4108368-5970165
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0264-6021
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
123
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
183-90
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:4108368-Animals,
pubmed-meshheading:4108368-Antibody Specificity,
pubmed-meshheading:4108368-Binding Sites,
pubmed-meshheading:4108368-Cattle,
pubmed-meshheading:4108368-Cephalosporins,
pubmed-meshheading:4108368-Cross Reactions,
pubmed-meshheading:4108368-Erythrocytes,
pubmed-meshheading:4108368-Haptens,
pubmed-meshheading:4108368-Hemagglutination Tests,
pubmed-meshheading:4108368-Immune Sera,
pubmed-meshheading:4108368-Models, Chemical,
pubmed-meshheading:4108368-Penicillin G,
pubmed-meshheading:4108368-Rabbits,
pubmed-meshheading:4108368-gamma-Globulins
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pubmed:year |
1971
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pubmed:articleTitle |
Specificities of haemagglutinating antibodies evoked by members of the cephalosporin C family and benzylpenicillin.
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pubmed:publicationType |
Journal Article
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