Linked Life Data

410719

Source:http://linkedlifedata.com/resource/pubmed/id/410719

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
41
pubmed:dateCreated
1977-12-29
pubmed:abstractText
Liver changes were studied after acut and subchronic exposition to mixtures of polychlorinated biphenyls (PCB) differing in their average chlorine content. Morphologically, the liver changes consisted mainly of cell hypertrophy and proliferation of the smooth endoplasmic reticulum (SER). After subchronic feeding the SER membranes formed membrane arrays. In addition to that the livers showed a hepatic porphyria. It was found that the porphyria was due to an inhibition of uroporphyrin decarboxylation similar to that caused by hexachlorobenzene. The porphyrinogenic effect was increased by feeding PCB containing more highly chlorinated components. Concomitant with the proliferation of the SER a high induction of membrane bound drug metabolizing enzymes could be observed. Duration and amount of induction increased with the chlorine content of the PCB. This could be correlated to the persistence to highly chlorinated components.
pubmed:language
ger
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0015-8178
pubmed:author
pubmed:issnType
Print
pubmed:day
3
pubmed:volume
95
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2487-92
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1977
pubmed:articleTitle
[Experimental liver changes by means of polychlorinated biphenyls (PCB)].
pubmed:publicationType
Journal Article, English Abstract