Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1971-7-6
pubmed:abstractText
Immunofluorescent studies using live cells from antibody-forming organs and anti-immunoglobulin antibodies demonstrate two populations of small lymphocytes which are differentiated by the presence or absence of Ig on their surface membranes. Most of the lymphocytes with detectable surface Ig appear to derive from cells of the bone marrow, while most of the Ig-negative lymphocytes derive from the thymus. Thus, adult mice thymectomized, lethally irradiated, and transplanted with bone marrow cells showed a normal number of lymphocytes with surface Ig but were depleted of the Ig-negative lymphocytes. Injection of thymocytes into these mice did not result in an increase in the number of lymphocytes with surface Ig in spleen and lymph nodes. Most of the injected thymocytes could be identified by means of histocompatibility markers. Also, the spleen and lymph nodes of neonatally thymectomized mice contained lymphocytes with surface Ig but were depleted of the Ig-negative lymphocytes. Attempts were made to identify light chains on thymocytes by a sensitive radioimmunoassay. In some experiments no light chains were detected and in others a small amount, i.e. no more than 2.6% of the amount present on spleen lymphocytes, could be detected. Whether these low figures are significant or represent a small amount of serum contamination is not clear as yet.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/4102685-14193155, http://linkedlifedata.com/resource/pubmed/commentcorrection/4102685-14279042, http://linkedlifedata.com/resource/pubmed/commentcorrection/4102685-4097588, http://linkedlifedata.com/resource/pubmed/commentcorrection/4102685-4099713, http://linkedlifedata.com/resource/pubmed/commentcorrection/4102685-4168095, http://linkedlifedata.com/resource/pubmed/commentcorrection/4102685-4189355, http://linkedlifedata.com/resource/pubmed/commentcorrection/4102685-4190976, http://linkedlifedata.com/resource/pubmed/commentcorrection/4102685-4919141, http://linkedlifedata.com/resource/pubmed/commentcorrection/4102685-4921784, http://linkedlifedata.com/resource/pubmed/commentcorrection/4102685-5305572, http://linkedlifedata.com/resource/pubmed/commentcorrection/4102685-5513502, http://linkedlifedata.com/resource/pubmed/commentcorrection/4102685-5691986, http://linkedlifedata.com/resource/pubmed/commentcorrection/4102685-5844812
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0022-1007
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
133
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1188-98
pubmed:dateRevised
2010-6-22
pubmed:meshHeading
pubmed:year
1971
pubmed:articleTitle
Immunoglobulins on the surface of lymphocytes. II. The bone marrow as the main source of lymphocytes with detectable surface-bound immunoglobulin.
pubmed:publicationType
Journal Article