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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1971-5-19
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pubmed:abstractText |
Transfer of live lymphoid cells from BGG-immunized strain 2 guinea pigs into syngeneic animals primed with DNP-OVA prepares the recipients for a markedly enhanced secondary anti-DNP antibody response upon challenge with DNP-BGG. This phenomenon has been demonstrated when the recipients were challenged 1 day after cell transfer, but it was considerably more striking when an interval of 6 days was allowed between transfer of cells and challenge with antigen. As demonstrated in the preceding paper (6), BGG preimmunization enhanced anti-DNP antibody responses to challenge with DNP-BGG. An analysis of the characteristics of substances to which preimmunization was effective in enhancing subsequent anti-hapten responses was made. It was shown that preimmunization of strain 13 guinea pigs with a copolymer of glutamic acid and lysine (GL), to which these animals are genetically unable to accord an immune response, failed to prepare them for an enhanced anti-DNP response to DNP-GL. Tolerance to BGG specifically abrogated the capacity of subsequent BGG immunization to prepare DNP-OVA primed rabbits for an enhanced anti-DNP response to DNP-BGG. Sensitization of animals to haptens by preimmunization with hapten-protein conjugates failed to prepare them for enhanced primary or secondary antibody responses to other determinants associated with that hapten on a different carrier. These studies indicate that the enhancing effect of carrier preimmunization reflects a cooperative interaction between lymphoid cells specific for carrier and cells specialized for haptenic determinants. Furthermore, the capacity of a substance to behave as a carrier requires more than its possession of a variety of antigenic determinants.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/4101345-13011399,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4101345-13163409,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4101345-13212051,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4101345-13745823,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4101345-13745824,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4101345-13836501,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4101345-13887798,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4101345-14279046,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4101345-14803635,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4101345-4101344,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4101345-4110123,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4101345-4181830,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4101345-4952101,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4101345-5412394,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4101345-5691985,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4101345-5691986,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4101345-5918139,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4101345-5938816,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4101345-6023661,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4101345-6067330,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4101345-6073028
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
132
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
283-99
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pubmed:dateRevised |
2010-6-22
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pubmed:meshHeading |
pubmed-meshheading:4101345-Animals,
pubmed-meshheading:4101345-Antibodies,
pubmed-meshheading:4101345-Antibody Formation,
pubmed-meshheading:4101345-Antibody Specificity,
pubmed-meshheading:4101345-Antigen-Antibody Reactions,
pubmed-meshheading:4101345-Dinitrophenols,
pubmed-meshheading:4101345-Epitopes,
pubmed-meshheading:4101345-Glycine,
pubmed-meshheading:4101345-Guinea Pigs,
pubmed-meshheading:4101345-Haptens,
pubmed-meshheading:4101345-Hemagglutination Tests,
pubmed-meshheading:4101345-Immune Tolerance,
pubmed-meshheading:4101345-Immunization,
pubmed-meshheading:4101345-Immunization, Passive,
pubmed-meshheading:4101345-Lymphocyte Transfusion,
pubmed-meshheading:4101345-Lymphocytes,
pubmed-meshheading:4101345-Lysine,
pubmed-meshheading:4101345-Ovalbumin,
pubmed-meshheading:4101345-Peptides,
pubmed-meshheading:4101345-Proteins,
pubmed-meshheading:4101345-Rabbits,
pubmed-meshheading:4101345-Species Specificity
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pubmed:year |
1970
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pubmed:articleTitle |
Carrier function in anti-hapten immune responses. II. Specific properties of carrier cells capable of enhancing anti-hapten antibody responses.
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pubmed:publicationType |
Journal Article
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