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pubmed:otherAbstract |
PIP: The effects of Ovosiston (3 mg chlormadinone acetate, .1 mg mestranol) on the endometrium were studied in 100 women with normal regular menstrual cycles during the 1st or 2nd treatment cycle. Endometrial tissue was obtained by curettage or by hysterectomy (in a few cases for various indications). Important variations from the normal cycle were observed. Glycogen formation in the glandular epithelium could be seen after only 3-4 days of treatment, and secretory activity was scarcely visible after 19 days. Instead, glands and stroma were increasingly atrophic, and atypical sinusoidal vessels developed. So contraceptive treatment (with combined preparations) results in abort ive artificial secretion in a deficiently proliferating endometrium, and not simply in postponement of the secretory phase. Ovosiston causes smaller histological changes in the endometrial cycle than preparations containing 19-nortestosterone acetate or its derivatives.
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