Linked Life Data

4094449

Source:http://linkedlifedata.com/resource/pubmed/id/4094449

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1986-3-31
pubmed:abstractText
The action of systemically administered Hydergine on the spontaneous neuronal firing of neurons located in various brain areas of the anaesthetized rat was investigated using conventional extracellular single cell recording techniques. Whereas locus coeruleus neurons were activated by both acute and repetitive injections of the drug, spontaneously active neurons of the medial septal nucleus, pyramidal cells of the hippocampus and unidentified neurons of the cingulate cortex were not affected. The possible functional consequences of the drug's activating action on locus coeruleus noradrenergic neurons are discussed. In view of the finding that noradrenaline affects the signal-to-noise ratio in various brain areas and given the widespread innervation pattern of noradrenergic fibers arising from locus coeruleus, Hydergine through its action on this brain area may potentially affect many brain regions.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0021-793X
pubmed:author
pubmed:issnType
Print
pubmed:volume
16 Suppl 3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
65-71
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Comparative electrophysiological investigations with Hydergine and other psychogeriatric agents on corticol and subcortical structures.
pubmed:publicationType
Journal Article, Comparative Study