Linked Life Data

4093998

Source:http://linkedlifedata.com/resource/pubmed/id/4093998

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1986-4-3
pubmed:abstractText
Rats were exposed to aerosols of iron-59 oxide (mass median aerodynamic diameter, MMAD = 1.6 micron, sigma g = 3.0) at a nominal concentration of 20 mg/m3 for 2 h to determine how a low lung burden (approximately 30 micrograms) of innocuous particles affects the size of the alveolar macrophage (AM) pool, and the functional status of the AM as assessed in vitro by their ability to exclude Trypan blue, adhere to plastic substrate, and bind and phagocytize sheep erythrocytes opsonized with immunoglobulin G (SRBC-IgG). Iron oxide deposition did not bring about significant changes in cell types or numbers of AM lavaged, AM viabilities, or the plastic substrate adherence characteristics of the AM. As of 1 d post exposure, however, the ability of AM to phagocytize SRBC-IgG increased. Phagocytosis was maximally enhanced 3-7 d post exposure and returned to control levels by 20 d after exposure. The increase in phagocytic activity correlated with an increase in AM avidities for SRBC-IgG. The kinetics of subsidence of the phagocytic response did not parallel the alveolar clearance rate of the deposited particles [t1/2 (biol)/53 d]. These studies show the deposition of a low lung burden of a noncytotoxic dust can transiently enhance Fc gamma-receptor-mediated particle binding and phagocytosis by AM.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0098-4108
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
855-68
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Characteristics of alveolar macrophages following the deposition of a low burden or iron oxide in the lung.
pubmed:publicationType
Journal Article, In Vitro, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.