Linked Life Data

4092608

Source:http://linkedlifedata.com/resource/pubmed/id/4092608

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1986-4-16
pubmed:abstractText
Administration of single doses (0.02 ml and 0.03 ml/g body wt.) of a solution of absolute alcohol (25%, v/v) in saline to MF1 mice on day 8 of gestation resulted in significant fetal mortality, growth retardation and gross malformations of the fetuses at term. The malformations included cranioschisis with exencephaly, maxillary hypoplasia, exophthalmia and various digital anomalies. The exencephalic fetuses, cleared in KOH and stained with alizarin red revealed the absence of the skull vault and hypoplasia of the facial bones. The skull base indicated under ossification and overcrowding of the constituent bones resulting in severe reduction in the cranial volume and asymmetry of cranial base. These cranial skeletal malformations were accompanied by abnormalities of the vertebral bodies, arches, ribs and sternum. It is concluded that acute doses of alcohol during critical stages of neural tube development is deleterious to both the central nervous system (CNS) and axial skeleton in the mouse.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0376-8716
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
215-27
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Exencephaly and axial skeletal dysmorphogenesis induced by acute doses of ethanol in mouse fetuses.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't