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rdf:type |
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lifeskim:mentions |
umls-concept:C0001962,
umls-concept:C0023779,
umls-concept:C0023884,
umls-concept:C0025746,
umls-concept:C0030012,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0204695,
umls-concept:C0205191,
umls-concept:C0456205,
umls-concept:C1280500,
umls-concept:C1550605,
umls-concept:C2697585
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pubmed:issue |
3
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pubmed:dateCreated |
1986-3-26
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pubmed:abstractText |
Feeding of ethanol in a liquid diet to male Wistar rats caused decreases in the hepatic cytosolic and mitochondrial [NAD+]/[NADH] ratios. This redox-state change was attenuated after 16 days of feeding ethanol as 36% of the total energy intake. Supplementation of the ethanol-containing liquid diet with Methylene Blue largely prevented the ethanol-induced redox state changes, but did not significantly decrease the severity of the hepatic lipid accumulation that resulted from ethanol ingestion. Methylene Blue did not affect body-weight gain, ethanol intake or serum ethanol concentrations in ethanol-fed rats, nor did the compound influence the hepatic redox state or liver lipid content of appropriate pair-fed control animals. These findings suggest that the altered hepatic redox state that results from ethanol oxidation is not primarily responsible for the production of fatty liver after long-term ethanol feeding in the rat.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/4091827-13761991,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4091827-16742812,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4091827-170139,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4091827-2857911,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4091827-4052166,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4091827-4291787,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4091827-4349663,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4091827-4549980,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4091827-4762602,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4091827-5031794,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4091827-5644651,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4091827-5696963,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4091827-5948329,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4091827-6021815,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4091827-6627849,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4091827-6751324,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4091827-6793493,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4091827-7362623
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0264-6021
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
232
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
877-82
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pubmed:dateRevised |
2010-9-13
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pubmed:meshHeading |
pubmed-meshheading:4091827-Animals,
pubmed-meshheading:4091827-Diet,
pubmed-meshheading:4091827-Ethanol,
pubmed-meshheading:4091827-Lipid Metabolism,
pubmed-meshheading:4091827-Liver,
pubmed-meshheading:4091827-Male,
pubmed-meshheading:4091827-Methylene Blue,
pubmed-meshheading:4091827-Oxidation-Reduction,
pubmed-meshheading:4091827-Rats,
pubmed-meshheading:4091827-Rats, Inbred Strains,
pubmed-meshheading:4091827-Triglycerides
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pubmed:year |
1985
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pubmed:articleTitle |
The effect of methylene blue on the hepatocellular redox state and liver lipid content during chronic ethanol feeding in the rat.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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