Linked Life Data

4091023

Source:http://linkedlifedata.com/resource/pubmed/id/4091023

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1986-2-24
pubmed:abstractText
In a large-scale investigation of circadian rhythms in endogenous depression, no free-running rhythms or indications of phase-advance were found in the patients compared with themselves after clinical recovery and with healthy controls. They exhibited a reduction of the amplitude of depression scales, partially due to a "ceiling effect" of highly elevated scores. A reduction of the amplitude of body temperature was probably related to a negative masking of the temperature rhythm by e.g. the patients' sleep disturbances. An increase in the amplitude of the cortisol rhythm, due to an elevation of the circadian maximum, was particularly pronounced in patients with significant diurnal variation in the severity of depression. It was thus probably related to a stress-induced positive masking of that rhythm. The acrophases of depression scores and the cortisol rhythm coincided roughly during but not outside depression. This may indicate a circadian modulation of the disease process and the activity of the hypothalamo-pituitary-adrenocortical system by the same clock-like mechanism within the hypothalamus.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0300-8967
pubmed:author
pubmed:issnType
Print
pubmed:volume
85
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
624-35
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:articleTitle
Are biological rhythms disturbed in depression?
pubmed:publicationType
Journal Article