Linked Life Data

4090524

Source:http://linkedlifedata.com/resource/pubmed/id/4090524

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1986-3-14
pubmed:abstractText
Caffeine disposition was studied over 24 h in rats on the 12th day of pregnancy given 80 mg/kg of drug as a single oral dose or in four divided doses every three hours. Peak blood levels of caffeine were reached at three hours after the single dose, and at 10 h (at half the previous value) after the first of the divided doses. At the end of the experiment both caffeine and its dimethylxanthine metabolites were higher in blood, amniotic fluid and fetuses after divided doses than after the single dose. Urinary excretion over 24 h was the same for the two groups. The overall conclusions underline that caffeine per se and not its metabolites are responsible for the teratogenic effects.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0049-8254
pubmed:author
pubmed:issnType
Print
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1045-51
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Caffeine disposition after oral administration to pregnant rats.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't