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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1980-1-28
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pubmed:abstractText |
It was initially reported that lipopolysaccharide (LPS)-unresponsive C3H/HeJ mice are refractory to LPS at the B-lymphocyte level, but more recently it has been shown that other cells are similarly unaffected. The current study was undertaken to study an in vivo LPS-modulated disease process involving macrophage-T cell interactions. Adult CBA/J and C3H/HeJ mice were used as spleen donors, and graft versus host reactions were induced in BALB/c neonates. Prior LPS treatment of CBA/J adults decreased the ability of their spleen cells to cause fatal graft versus host disease in BALB/c neonates, whereas no difference was found between injection of spleen cells from normal or LPS-treated C3H/HeJ mice. Similar results were obtained with these cell types when the mouse spleen mixed leukocyte culture system was used. In a carbon clearance assay for stimulation of the reticuloendothelial system with LPS, it was found that the rate of phagocytosis was significantly increased in BALB/c and CBA/J mice 72 h after inoculation of LPS. No stimulation was seen in rate of carbon uptake in the C3H/HeJ animals after treatment with phenol-extracted LPS or with butanol-extracted LPS. An LPS-induced protective serum factor was produced only in the LPS-responsive CBA/J mice and was specific for the syngeneic cells.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/40877-1085775,
http://linkedlifedata.com/resource/pubmed/commentcorrection/40877-1104747,
http://linkedlifedata.com/resource/pubmed/commentcorrection/40877-123543,
http://linkedlifedata.com/resource/pubmed/commentcorrection/40877-129492,
http://linkedlifedata.com/resource/pubmed/commentcorrection/40877-182900,
http://linkedlifedata.com/resource/pubmed/commentcorrection/40877-25306,
http://linkedlifedata.com/resource/pubmed/commentcorrection/40877-304417,
http://linkedlifedata.com/resource/pubmed/commentcorrection/40877-333293,
http://linkedlifedata.com/resource/pubmed/commentcorrection/40877-4138849,
http://linkedlifedata.com/resource/pubmed/commentcorrection/40877-4559167,
http://linkedlifedata.com/resource/pubmed/commentcorrection/40877-4616077,
http://linkedlifedata.com/resource/pubmed/commentcorrection/40877-46249,
http://linkedlifedata.com/resource/pubmed/commentcorrection/40877-4877918,
http://linkedlifedata.com/resource/pubmed/commentcorrection/40877-4941003,
http://linkedlifedata.com/resource/pubmed/commentcorrection/40877-4942636,
http://linkedlifedata.com/resource/pubmed/commentcorrection/40877-5797695,
http://linkedlifedata.com/resource/pubmed/commentcorrection/40877-5957260,
http://linkedlifedata.com/resource/pubmed/commentcorrection/40877-627714,
http://linkedlifedata.com/resource/pubmed/commentcorrection/40877-702060,
http://linkedlifedata.com/resource/pubmed/commentcorrection/40877-773822,
http://linkedlifedata.com/resource/pubmed/commentcorrection/40877-804483,
http://linkedlifedata.com/resource/pubmed/commentcorrection/40877-965087
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0019-9567
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
137-42
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:40877-Animals,
pubmed-meshheading:40877-Female,
pubmed-meshheading:40877-Graft vs Host Reaction,
pubmed-meshheading:40877-Lipopolysaccharides,
pubmed-meshheading:40877-Lymphocyte Culture Test, Mixed,
pubmed-meshheading:40877-Macrophages,
pubmed-meshheading:40877-Male,
pubmed-meshheading:40877-Mice,
pubmed-meshheading:40877-Mice, Inbred BALB C,
pubmed-meshheading:40877-Mice, Inbred C3H,
pubmed-meshheading:40877-Mice, Inbred CBA,
pubmed-meshheading:40877-Phagocytosis,
pubmed-meshheading:40877-T-Lymphocytes
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pubmed:year |
1979
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pubmed:articleTitle |
Influence of lipopolysaccharide on graft versus host reactivity of lipopolysaccharide-unresponsive C3H/HeJ mice.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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