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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
1986-3-3
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pubmed:abstractText |
The aqueous solution chemistry of the C-3'-acetoxy moiety of cephalothin sodium (1b) was examined with the use of isotopically labeled H2(18)O and [2-13C]acetate anion. The 18O incorporation studies indicate that the hydrolysis (at pH 4.7 +/- 0.1) of 1b to the deacetyl derivative of cephalothin (2b) proceeds via two pathways: alkyl-oxygen bond cleavage (55-63%) and acyl-oxygen bond cleavage accounting for the remainder. The incorporation of [2-13C]acetate into 1b suggests that the alkyl-oxygen cleavage pathway is a reversible reaction.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0022-3549
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
74
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1162-6
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:4087175-Cephalosporins,
pubmed-meshheading:4087175-Cephalothin,
pubmed-meshheading:4087175-Chemical Phenomena,
pubmed-meshheading:4087175-Chemistry,
pubmed-meshheading:4087175-Crystallization,
pubmed-meshheading:4087175-Dealkylation,
pubmed-meshheading:4087175-Hydrolysis,
pubmed-meshheading:4087175-Magnetic Resonance Spectroscopy,
pubmed-meshheading:4087175-Mass Spectrometry,
pubmed-meshheading:4087175-Oxygen,
pubmed-meshheading:4087175-Oxygen Radioisotopes
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pubmed:year |
1985
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pubmed:articleTitle |
Cephalothin: hydrolysis of the C-3'-acetoxy moiety of a 7-aminocephalosporanic acid; observation of both acyl-oxygen bond cleavage and reversible alkyl-oxygen bond cleavage.
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pubmed:publicationType |
Journal Article
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