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rdf:type |
|
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lifeskim:mentions |
|
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pubmed:issue |
5
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pubmed:dateCreated |
1986-2-7
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pubmed:abstractText |
The aim of the experiments presented here is the selective inhibition of an antigen-specific immune response. Antigen receptors are used as targets for conjugates of antigens and toxin to eliminate antigen-reactive cells. The trinitrophenol (TNP)-specific immune response can be specifically abrogated by incubating the TNP-keyhole limpet haemocyanin (KLH)-primed spleen cells with TNP-ricin or TNP-chicken IgG-ricin conjugates before in vitro stimulation with TNP-KLH. The rate of elimination is dose-dependent and related to the degree of TNP moieties bound to the toxin molecule. The specificity of the toxin conjugates is demonstrated by treating sheep erythrocyte-primed spleen cells with TNP-IgG-ricin conjugates. These results may have therapeutic relevance for treating autoimmune diseases.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0300-9475
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
489-94
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:4081646-Animals,
pubmed-meshheading:4081646-Antibody Formation,
pubmed-meshheading:4081646-Antibody Specificity,
pubmed-meshheading:4081646-Antibody-Producing Cells,
pubmed-meshheading:4081646-Haptens,
pubmed-meshheading:4081646-Hemocyanin,
pubmed-meshheading:4081646-Immunoglobulin G,
pubmed-meshheading:4081646-Mice,
pubmed-meshheading:4081646-Nitrobenzenes,
pubmed-meshheading:4081646-Receptors, Antigen, B-Cell,
pubmed-meshheading:4081646-Ricin,
pubmed-meshheading:4081646-Trinitrobenzenes
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pubmed:year |
1985
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|
pubmed:articleTitle |
Elimination of trinitrophenol-specific antibody response by antigen-toxin conjugates.
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pubmed:publicationType |
Journal Article
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