Linked Life Data

4080756

Source:http://linkedlifedata.com/resource/pubmed/id/4080756

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1986-2-13
pubmed:abstractText
Following injection of histidine (as 1-histidine monohydrochloride, 500 mg/kg, IP) rats showed a suppression of total food intake within the first 2 hours of a 12 hour daily feeding period but not if the rats were adapted to a 4 hour daily feeding period. Furthermore, rats adapted to a nocturnal as compared to a diurnal 12 hour feeding period showed a greater response (50% vs. 20% suppression of feeding) to histidine. Overall, within an experiment, food intake suppression correlated with the histidine dose (0, 125, 250, 375 and 500 mg/kg; for mean response r(3) = 0.90, p less than 0.05) although the lowest dose measured to be effective in a cross-over design experiment was 375 mg/kg. No differential effect upon protein or carbohydrate intake was observed in any of the studies. The effects of injections of 250 and 500 mg/kg histidine on food intake were associated with significant elevations of brain histidine and histamine. We conclude that histidine, possibly by changes in brain histidine, influences total food intake but not macronutrient selection.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0091-3057
pubmed:author
pubmed:issnType
Print
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
721-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Food intake suppression by histidine.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't