Linked Life Data

4080716

Source:http://linkedlifedata.com/resource/pubmed/id/4080716

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1986-2-7
pubmed:abstractText
Administration of 3,4-dimethoxyphenylethylamine, (DMPEA) which has been incubated with blood plasma from unmedicated, acute schizophrenics, to aggregated mice pretreated with the monoamine oxidase inhibitor, phenylisobutylhydrazine, has been shown to produce an amphetamine-like excitatory, lethal response in such mice. Use of blood plasma from 92 unmedicated, acute schizophrenics in the test system giving that response yielded 82 positive responses (89%) and 10 negative responses (11%). Substitution of the blood plasmas from 94 non-schizophrenics analogously into this test system produced 2 positive responses (2%) and 92 negative responses (98%). When plasma from schizophrenics medicated with antipsychotic tranquilizers were tested in the system, none gave positive response, 58 gave negative response. If the compound bis-N, N dimethoxyphenylethylamine (bis-DMPEA) was either added to DMPEA or substituted for it and incubated with inactive blood plasma taken from non-schizophrenics in the incubation step of the test system a marked positive response was elicited. The results obtained are compatible with a hypothesis which postulates function of a DMPEA metabolite as a pathologic endocoid in schizophrenic reaction.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0361-7742
pubmed:author
pubmed:issnType
Print
pubmed:volume
192
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
387-93
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Projection of an endocoid involved with schizophrenic reaction.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't