Linked Life Data

4078952

Source:http://linkedlifedata.com/resource/pubmed/id/4078952

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1986-1-28
pubmed:abstractText
The muscle coat of the lower esophageal sphincter (LES) of seven patients with achalasia and three patients with a hypertensive sphincter has been studied with the electron microscope. In these pathological conditions the ultrastructural pictures differ both from normal and from one another. In achalasia, the LES muscle wall components (nerve endings, smooth muscle cells, interstitial cells of Cajal and connective tissue) are altered, but, while all the nerve endings and interstitial cells are affected, only a few smooth muscle cells are damaged. The severity of the alterations is more pronounced in the older patients. On the contrary, there is no damage of the muscle wall components in the hypertensive sphincter, whereas an increase in the cytoplasmic organelles (smooth endoplasmic reticulum and mitochondria) has been found in all interstitial cells and in some smooth muscle cells. Moreover, the ultrastructural picture of the hypertensive sphincter does not seem to change with patients' age. Since the LES components specifically altered in achalasia are the nerve endings and the interstitial cells of Cajal, they are regarded as principally responsible for the altered motility. On the contrary, the ultrastructural picture of the hypertensive sphincter suggests an enhancement of the activity of the activity of all the interstitial cells and of some smooth muscle cell; therefore, we consider the hyperfunction of these cells as the cause of this esophageal motor disorder.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0022-4782
pubmed:author
pubmed:issnType
Print
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
673-85
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
The muscle coat of the lower esophageal sphincter in patients with achalasia and hypertensive sphincter. An electron microscopic study.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't