Linked Life Data

407841

Source:http://linkedlifedata.com/resource/pubmed/id/407841

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1977-9-17
pubmed:abstractText
This investigation was undertaken to determine whether either d-primaquine or l-primaquine has sufficient advantage over primaquine to warrant evaluation for curative activity in human volunteers infected with Plasmodium vivax. It was found: (i) that the capacities of the isomers and the racemate to cure infections with Plasmodium cynomolgi in rhesus monkeys were essentially identical; (ii) that the subacute toxicities of the isomers and racemate for this monkey were qualitatively the same, but that l-primaquine was three to five times as toxic as d-primaquine and at least twice as toxic as primaquine; and (iii) that the acute single-dose toxicities of the isomers for mice were not only qualitatively different, but that the d isomer was at least four times as toxic as l-primaquine. Since previous appraisals of curative activity and tolerability of 8-aminoquinolines in rhesus monkeys have correlated well with appraisals in human volunteers, attention was focused on results acquired with these test subjects. The relevant evaluations showed that d-primaquine had a therapeutic index at least twice that of primaquine. If this advantage carries over to man, problems that now complicate routine use of primaquine might be obviated. Therefore, a critical comparison of d-primaquine and primaquine in human volunteers seems indicated.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/407841-13104803, http://linkedlifedata.com/resource/pubmed/commentcorrection/407841-13104806, http://linkedlifedata.com/resource/pubmed/commentcorrection/407841-13793053, http://linkedlifedata.com/resource/pubmed/commentcorrection/407841-14044759, http://linkedlifedata.com/resource/pubmed/commentcorrection/407841-14361898, http://linkedlifedata.com/resource/pubmed/commentcorrection/407841-14804087, http://linkedlifedata.com/resource/pubmed/commentcorrection/407841-14945978, http://linkedlifedata.com/resource/pubmed/commentcorrection/407841-16695632, http://linkedlifedata.com/resource/pubmed/commentcorrection/407841-326072, http://linkedlifedata.com/resource/pubmed/commentcorrection/407841-405875, http://linkedlifedata.com/resource/pubmed/commentcorrection/407841-5795444
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0066-4804
pubmed:author
pubmed:issnType
Print
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
51-60
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1977
pubmed:articleTitle
Comparison of the curative antimalarial activities and toxicities of primaquine and its d and l isomers.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, Non-P.H.S.