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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1986-1-28
|
| pubmed:abstractText |
The characteristics and topographical distribution of monoiodo 125I-Tyr3-neurotensin (NT) binding sites in normal human brain tissue were studied on brain sections and by quantitative autoradiography. Sections at the level of the substantia nigra show a dissociation constant and maximal binding capacity of 4.8 +/- 0.8 nM and 70 +/- 7 fmol/mg protein, respectively. High density of 125I-NT binding sites were mainly found in dopaminergic (DA)-rich areas such as the substantia nigra, the ventral tegmental area, the striatum and the nucleus accumbens, further supporting an interaction between NT and DA neurons in human brain.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0006-8993
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
2
|
| pubmed:volume |
348
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
375-80
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:4075096-Aged,
pubmed-meshheading:4075096-Autoradiography,
pubmed-meshheading:4075096-Binding Sites,
pubmed-meshheading:4075096-Brain,
pubmed-meshheading:4075096-Cerebral Cortex,
pubmed-meshheading:4075096-Corpus Striatum,
pubmed-meshheading:4075096-Dopamine,
pubmed-meshheading:4075096-Humans,
pubmed-meshheading:4075096-Hypothalamus,
pubmed-meshheading:4075096-Neurotensin,
pubmed-meshheading:4075096-Nucleus Accumbens
|
| pubmed:year |
1985
|
| pubmed:articleTitle |
Characterization and autoradiographic distribution of neurotensin binding sites in the human brain.
|
| pubmed:publicationType |
Journal Article
|