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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1986-2-12
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pubmed:abstractText |
An intravenous K+-sensitive electrode has been used to monitor plasma [K+] changes induced by alpha- and beta-adrenoceptor agonists in anaesthetized guinea-pigs, rabbits and rats. The effects of phentolamine and propranolol on these responses were studied. In the guinea-pig both alpha- and beta-adrenoceptor agonists produced a biphasic response consisting of an initial rapid increase in [K+] which was followed, within 1 min, by a fall below baseline. The antagonist studies indicated that in this species both phases of the response could be elicited by either alpha- or beta-adrenoceptor activation. In the rabbit the responses were both slower and smaller than those seen in the guinea-pig and required larger agonist doses. In addition it was found that the increase in plasma [K+] was alpha-adrenoceptor-mediated while the subsequent fall was seen only with beta-adrenoceptor activation. In the rat triphasic changes in plasma [K+] were seen consisting of an initial decrease which was alpha-adrenoceptor-mediated, followed by an increase and then a second fall which was elicited by beta-adrenoceptor stimulation. The increase in plasma [K+] was only slightly reduced by either alpha- or beta-adrenoceptor antagonists. Apamin, a toxin from bee venom which blocks Ca2+-activated K+-channels, was found to block the hyperkalaemic phase of the response in the guinea-pig and rabbit but had no effect in the rat. It is concluded that there are marked species differences in the effects of adrenoceptor agonists on plasma [K+] in vivo.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/4075019-13212649,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4075019-13533567,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4075019-13900,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4075019-14098328,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4075019-16994748,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4075019-2116,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4075019-228203,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4075019-240432,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4075019-35537,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4075019-4397294,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4075019-4413113,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4075019-5013151,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4075019-5076396,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4075019-5296054,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4075019-5831041,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4075019-6091825,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4075019-6139136,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4075019-6273550,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4075019-6282648,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4075019-6295755,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4075019-6305417,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4075019-7125263,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4075019-947205
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Angiotensin II,
http://linkedlifedata.com/resource/pubmed/chemical/Apamin,
http://linkedlifedata.com/resource/pubmed/chemical/Epinephrine,
http://linkedlifedata.com/resource/pubmed/chemical/Ethanolamines,
http://linkedlifedata.com/resource/pubmed/chemical/Isoproterenol,
http://linkedlifedata.com/resource/pubmed/chemical/Methoxamine,
http://linkedlifedata.com/resource/pubmed/chemical/Oxymetazoline,
http://linkedlifedata.com/resource/pubmed/chemical/Phentolamine,
http://linkedlifedata.com/resource/pubmed/chemical/Phenylephrine,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium,
http://linkedlifedata.com/resource/pubmed/chemical/Propranolol,
http://linkedlifedata.com/resource/pubmed/chemical/Sympatholytics,
http://linkedlifedata.com/resource/pubmed/chemical/Sympathomimetics,
http://linkedlifedata.com/resource/pubmed/chemical/amidephrine
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0007-1188
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
86
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
827-36
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:4075019-Anesthesia,
pubmed-meshheading:4075019-Angiotensin II,
pubmed-meshheading:4075019-Animals,
pubmed-meshheading:4075019-Apamin,
pubmed-meshheading:4075019-Blood Pressure,
pubmed-meshheading:4075019-Epinephrine,
pubmed-meshheading:4075019-Ethanolamines,
pubmed-meshheading:4075019-Guinea Pigs,
pubmed-meshheading:4075019-Isoproterenol,
pubmed-meshheading:4075019-Male,
pubmed-meshheading:4075019-Methoxamine,
pubmed-meshheading:4075019-Oxymetazoline,
pubmed-meshheading:4075019-Phentolamine,
pubmed-meshheading:4075019-Phenylephrine,
pubmed-meshheading:4075019-Potassium,
pubmed-meshheading:4075019-Propranolol,
pubmed-meshheading:4075019-Rabbits,
pubmed-meshheading:4075019-Rats,
pubmed-meshheading:4075019-Rats, Inbred Strains,
pubmed-meshheading:4075019-Species Specificity,
pubmed-meshheading:4075019-Sympatholytics,
pubmed-meshheading:4075019-Sympathomimetics
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pubmed:year |
1985
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pubmed:articleTitle |
The effects of adrenoceptor agonists and antagonists on plasma potassium concentration in anaesthetized guinea-pigs, rabbits and rats.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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