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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1986-1-15
|
| pubmed:abstractText |
Mammalian spermine synthase activity was strongly inhibited by S-methyl-5'-methylthioadenosine. This nucleoside was readily taken up by SV-3T3 cells and blocked the synthesis of spermine by these cells. However, there was a corresponding increase in spermidine content and there was no effect on cell growth. These results indicate that S-methyl-5'-methylthioadenosine should be a useful compound to evaluate the role of spermine in mammalian cell physiology and that in at least one cell line the synthesis of spermine is not required for a normal growth rate.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0006-291X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
27
|
| pubmed:volume |
133
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
82-9
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:4074381-Adenosine,
pubmed-meshheading:4074381-Animals,
pubmed-meshheading:4074381-Cell Division,
pubmed-meshheading:4074381-Cell Line,
pubmed-meshheading:4074381-Mice,
pubmed-meshheading:4074381-Spermine,
pubmed-meshheading:4074381-Spermine Synthase,
pubmed-meshheading:4074381-Thionucleosides
|
| pubmed:year |
1985
|
| pubmed:articleTitle |
Growth of mammalian cells in the absence of the accumulation of spermine.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|