|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0002508,
umls-concept:C0023317,
umls-concept:C0036679,
umls-concept:C0086543,
umls-concept:C0205355,
umls-concept:C0205390,
umls-concept:C0230445,
umls-concept:C0237868,
umls-concept:C0301625,
umls-concept:C0392747,
umls-concept:C0450442,
umls-concept:C1554963
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|
pubmed:issue |
1
|
|
pubmed:dateCreated |
1986-1-15
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|
pubmed:abstractText |
Low temperature induced opacification (cold cataract) of the nucleus of young mammalian lenses is associated with a phase separation of proteins in the lens cell cytoplasm. Calf lenses were treated with a variety of imido-esters and N-hydroxysuccinimide-esters, which react specifically with amino groups. Many potent inhibitors of phase separation cataract were identified which lower the opacification temperature by 6 degrees C or more. Lenses generally remain clear, colorless and soft. Furthermore, suppression of the cold cataract temperature is permanent upon removal of excess reagent.
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pubmed:grant |
|
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pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Nov
|
|
pubmed:issn |
0006-291X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
27
|
|
pubmed:volume |
133
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
239-47
|
|
pubmed:dateRevised |
2008-11-21
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|
pubmed:meshHeading |
|
|
pubmed:year |
1985
|
|
pubmed:articleTitle |
Permanent suppression of phase separation cataract in calf lens using amine modification agents.
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|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
