Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1986-1-22
pubmed:abstractText
In acute experiments in dogs anesthetized with pentobarbital, pressor responses produced by the i.v. injection of serotonin, noradrenaline and electric stimulation of the sympathetic nerves of the spleen, were registered before the i.v. injection of cianopramine (Ro 11-2465), a potent inhibitor of the uptake of serotonin into 5-HT neurones. Doses of 0.1 to 0.5 mg/kg of the antidepressant did not modify the blood pressure, while these produced a more intensive and prolonged pressor response during the i.v. injection of serotonin (p less than 0.05), noradrenaline (p less than 0.001) and stimulation of the splenic nerves (p less than 0.005). These effects resulted from the inhibition of the presynaptic reuptake of monoamines. The i.v. injection of 1-2 mg/kg of cianopramine produced significant hypotension (p less than 0.001) with baroreceptor and serotoninergic responses blockade. An induced strong hypertensive dose-dependent effect was observed after the i.v. administration of noradrenaline (+82%) and stimulation of splenic nerves (+80%). Cianopramine did not affect the hypotension produced by carbachol and histamine. The peripheric action of cianopramine showed a higher inhibitory effect on the presynaptic reuptake of noradrenaline than on serotonin.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0278-5846
pubmed:author
pubmed:issnType
Print
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
381-6
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Cardiovascular peripheric effects of a new tricyclic antidepressant, cianopramine (Ro 11-2465) in dogs.
pubmed:publicationType
Journal Article