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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
10
|
pubmed:dateCreated |
1986-1-21
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pubmed:abstractText |
Ganglioside GM1 was labeled with 125I either directly or after conjugation to tyramine. Direct iodination of the sphingosine chain resulted in a compound which dehalogenated rapidly both in vitro and in vivo. The binding of the 125I[GM1-tyramine] conjugate to neuronal membranes in vitro was similar to that reported for 3H-GM1. The biodistribution of 125I activity after intravenous injection of 0.5 uM and 5 uM 125I[GM1-tyramine] in mice was also similar to that reported for 3H-GM1. This radioiodinated GM1 derivative might be useful for the study of ganglioside GM1 function in vivo.
|
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Oct
|
pubmed:issn |
0031-6989
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
17
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
897-912
|
pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:4070340-Animals,
pubmed-meshheading:4070340-G(M1) Ganglioside,
pubmed-meshheading:4070340-Iodine Radioisotopes,
pubmed-meshheading:4070340-Male,
pubmed-meshheading:4070340-Micelles,
pubmed-meshheading:4070340-Neurons,
pubmed-meshheading:4070340-Rats,
pubmed-meshheading:4070340-Rats, Inbred Strains,
pubmed-meshheading:4070340-Time Factors,
pubmed-meshheading:4070340-Tissue Distribution
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pubmed:year |
1985
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pubmed:articleTitle |
Radioiodinated ganglioside GM1: a potential tool for the investigation of ganglioside function in vivo.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|