Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
11
|
pubmed:dateCreated |
1985-12-27
|
pubmed:abstractText |
A series of novel 1,1'-(4,1-phenylene)bis [1,6-dihydro-6,6-dimethyl-1,3,5-triazine-2,4-diamines] was prepared and evaluated for activity against Trypanosoma rhodesiense in mice. The importance of the bis structure and the nature of the spacer between the two phenyl rings for optimal activity have been revealed. The potent parenteral activity of several analogues within this series as well as preliminary indication of oral activity lends encouragement to further development of this structural class.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Nov
|
pubmed:issn |
0022-2623
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
28
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1728-40
|
pubmed:dateRevised |
2008-11-21
|
pubmed:meshHeading |
pubmed-meshheading:4067999-Animals,
pubmed-meshheading:4067999-Chemical Phenomena,
pubmed-meshheading:4067999-Chemistry,
pubmed-meshheading:4067999-Diamines,
pubmed-meshheading:4067999-Hot Temperature,
pubmed-meshheading:4067999-Magnetic Resonance Spectroscopy,
pubmed-meshheading:4067999-Mice,
pubmed-meshheading:4067999-Structure-Activity Relationship,
pubmed-meshheading:4067999-Triazines,
pubmed-meshheading:4067999-Trypanosomiasis
|
pubmed:year |
1985
|
pubmed:articleTitle |
Novel bis[1,6-dihydro-6,6-dimethyl-1,3,5-triazine-2,4-diamines] as antitrypanosomal agents.
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, Non-P.H.S.
|