Linked Life Data

4065388

Source:http://linkedlifedata.com/resource/pubmed/id/4065388

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1986-1-16
pubmed:abstractText
Recently, the serotonergic nervous system has been receiving attention as part of the blood pressure regulating mechanism of the central nervous system, and it has been postulated that the system may participate in the pathogenesis of hypertension. The purpose of this experiment is to investigate the mechanism of hemodynamic change after i.c.v. administration of 5-HT in SHR and in normotensive Wistar Rats (WR). MATERIALS AND METHODS: Twenty-week-old male SHR (n = 11) and age-matched WR (n = 14) were used. On the day before the experiments, the unilateral carotid artery and jugular vein were cannulated. Also, a cannula was inserted stereotaxically into the anterior horn of the lateral cerebral ventricle. Experiments were performed under the conscious and minimum restrained state. Experiment I: After observation of resting mean arterial pressure (MAP) and heart rate (HR) for 20 minutes, 5-HT (5 micrograms/5 microliter saline) was administrated i.c.v., and MAP and HR were observed for 90 minutes. Then, 200 micrograms of phenoxybenzamine (POB) was given from the jugular cannula. Thirty minutes after the POB administration when MAP was stabilized, 5 micrograms of 5-HT was again given i.c.v., and MAP and HR were recorded for 30 minutes. Experiment II: Plasma norepinephrine (PNE) was measured before and 2 minutes after 5-HT i.c.v. administration. The control sample (1.5 ml) was withdrawn at least 30 minutes before the 5-HT injection, and immediately after the blood sampling, the same amount of blood which was obtained from the age-matched donor rat of the same strain was transfused. RESULTS: Experiment I: Resting MAP was 136.4 +/- 5.1 mmHg in SHR and 99.1 +/- 3.0 mmHg in WR. I.c.v. administration of 5-HT elicited consistent pressor response in SHR and in WR.(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:language
jpn
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0029-0661
pubmed:author
pubmed:issnType
Print
pubmed:day
20
pubmed:volume
61
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
775-83
pubmed:dateRevised
2011-7-27
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
[Effects of intracerebroventricular (I.C.V.) administration of 5-hydroxytryptamine (5-HT) on hemodynamics in conscious spontaneously hypertensive rats (SHR): relation to sympathetic nervous system].
pubmed:publicationType
Journal Article, English Abstract