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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
11
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pubmed:dateCreated |
1985-12-27
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pubmed:abstractText |
The antidiuretic activity of oxytocin (OT) was measured in Brattleboro rats with congenital diabetes insipidus. A dose dependent antidiuretic response was found in animals receiving chronic infusions of 0.1 micrograms/h, 1.0 micrograms/h, and 5 micrograms/h of OT. OT infused at the rate of 5 micrograms/h over a 7-day period completely reversed the symptoms of diabetes insipidus. The results support the concept that OT serves as a weak agonist of vasopressin at the level of the kidney and at pharmacological levels exhibits antidiuretic activity.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0014-4754
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
41
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1444-6
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:4065302-Animals,
pubmed-meshheading:4065302-Diabetes Insipidus,
pubmed-meshheading:4065302-Diuresis,
pubmed-meshheading:4065302-Dose-Response Relationship, Drug,
pubmed-meshheading:4065302-Male,
pubmed-meshheading:4065302-Oxytocin,
pubmed-meshheading:4065302-Rats,
pubmed-meshheading:4065302-Rats, Brattleboro
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pubmed:year |
1985
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pubmed:articleTitle |
Antidiuretic effects of oxytocin in the Brattleboro rat.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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