Linked Life Data

4061917

Source:http://linkedlifedata.com/resource/pubmed/id/4061917

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1985-12-20
pubmed:abstractText
To determine the effects of vasomotor tone on intrathoracic and splanchnic blood volume, the distribution of radioactively (99mTc) labeled erythrocytes was recorded by whole body scintigraphy before and during peridural anesthesia (PDA) in eight supine men. The radioactivity was recorded with a gamma camera and its distribution determined in the thorax, abdomen, and limbs. Arterial and central venous pressure, heart rate, and calf volume and flow also were measured. During PDA with a sensory block up to T4/5, radioactivity increased only in the denervated legs (+ 9.9 +/- 2.3% SE), whereas it decreased in all other regions, i.e., in the thorax (-8.1 +/- 1.2%), the innervated upper limbs (-10.6 +/- 4.0%), and in the splanchnic vasculature (-5 +/- 1.7%). However, in two of the subjects, after an initial decrease, splanchnic blood content increased while intrathoracic blood volume decreased further. The effects of PDA on thoracic and splanchnic filling could be duplicated by the sequestration of about 500-600 ml of blood in both legs. In supine humans high peridural anesthesia evokes the same decrease in intrathoracic blood volume as orthostasis. This seems to be counteracted by a reflex decrease in filling of the denervated muscle and skin areas and also by a constriction of the splanchnic vasculature by an unknown mechanism. Potential circulatory collapse may ensue when the vasoconstrictor response fails in the splanchnic circulation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0003-3022
pubmed:author
pubmed:issnType
Print
pubmed:volume
63
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
616-23
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Peridural anesthesia and the distribution of blood in supine humans.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't