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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5 Pt 1
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pubmed:dateCreated |
1985-12-12
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pubmed:abstractText |
Radioimmunoassays for both human copper-zinc and manganous superoxide dismutases (Cu-Zn SOD and Mn SOD, respectively) have been developed, validated, and utilized to measure the concentrations of these enzymes in cultured monocytes. Monocyte Mn SOD increased 4.7-fold over basal during 3 days of culture, an increase that was markedly enhanced by stimulation with bacterial lipopolysaccharide (LPS). Cu-Zn SOD showed a transient decrease over the culture period but was unaffected by LPS. Stimulation with muramyl dipeptide had minimal effect on Mn SOD and no effect on Cu-Zn SOD during culture, even at a concentration capable of activating the monocytes, as defined by zymosan-induced superoxide production.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0002-9513
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
249
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
C393-7
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:4061626-Acetylmuramyl-Alanyl-Isoglutamine,
pubmed-meshheading:4061626-Enzyme Induction,
pubmed-meshheading:4061626-Humans,
pubmed-meshheading:4061626-Lipopolysaccharides,
pubmed-meshheading:4061626-Monocytes,
pubmed-meshheading:4061626-Radioimmunoassay,
pubmed-meshheading:4061626-Stimulation, Chemical,
pubmed-meshheading:4061626-Superoxide Dismutase,
pubmed-meshheading:4061626-Zymosan
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pubmed:year |
1985
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pubmed:articleTitle |
Selective induction of manganous superoxide dismutase in human monocytes.
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pubmed:publicationType |
Journal Article
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