Linked Life Data

4059031

Source:http://linkedlifedata.com/resource/pubmed/id/4059031

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1985-12-3
pubmed:abstractText
45Ca2+ exchange was studied in small pieces of canine left ventricular free wall. The loss of 45Ca2+ from 45Ca2+ equilibrated tissue into ice-cold (4 degrees C) "wash" medium could be best fitted with a model containing a minimum of 3 compartments. 45Ca2+ uptake into and 45Ca2+ efflux from the most slowly exchanging compartment (compartment 3) at 37 degrees C allowed it to be subdivided into two fractions; a rapidly exchanging fraction (t1/2 approximately 1.25 min) and a slowly exchanging fraction (t1/2 approximately 50 min). The total Ca2+ content of compartment 3 was enhanced by isoproterenol but little affected by caffeine. The slow t1/2 for exchange of the Ca2+ in compartment 3 at 4 degrees C and its increased Ca2+ content following isoproterenol treatment suggest that this compartment contains some Ca2+ of intracellular origin. In addition, the finding that the rapidly exchanging part of compartment 3 could be preserved by cooling the tissue to 4 degrees C shows that rapidly exchanging Ca2+ compartments can be studied in superfused cardiac preparations using this technique. Action potentials, elicited by electrical stimulation of the tissue, caused large changes in the Ca2+ content of compartment 3 (up to 170 muM/kg) indicating that this postulated intracellular compartment may play a significant role in the normal contraction-relaxation cycle.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0031-6768
pubmed:author
pubmed:issnType
Print
pubmed:volume
405
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
37-45
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Calcium exchange in the resting and electrically stimulated canine myocardium.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't