Linked Life Data

4058675

Source:http://linkedlifedata.com/resource/pubmed/id/4058675

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1985-12-18
pubmed:abstractText
Central cholinergic pathways have been implicated in the control of pituitary hormone release. Based on studies using acetylcholinesterase (AChE) histochemistry, it has been proposed that the cholinergic neurons controlling hormone release originate in neurons of the arcuate nucleus (AH). Although AChE histochemistry has been widely utilized to map central cholinergic pathways, AChE is not an unequivocal marker for cholinergic neurons. A more precise method for determining that neurons are cholinergic is the immunocytochemical labeling of choline acetyltransferase (CAT). In order to determine if the AChE-positive neurons in the AH are cholinergic, we double-labeled tissue sections for CAT and AChE using a combined immunocytochemical and AChE-histochemical method. Although neurons in several areas of the brain could be labeled for both CAT and AChE, neurons in the AH were only AChE-positive. We concluded that the AChE-positive neurons in the AH may be cholinoceptive but are not likely to be the source of cholinergic neurons controlling hormone release from the pituitary gland.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0028-3835
pubmed:author
pubmed:issnType
Print
pubmed:volume
41
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
427-31
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Evidence that cell bodies in the arcuate nucleus of the hypothalamus are not cholinergic.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.