Linked Life Data

40582

Source:http://linkedlifedata.com/resource/pubmed/id/40582

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1979-12-27
pubmed:abstractText
Earlier experiments in vivo with adrenalectomized rats showed that for the induction of tryptophan oxygenase and tyrosine aminotransferase small doses of cortisone acetate and the corresponding substrate are necessary. We performed the similar experiments in vitro with liver slices from adrenalectomized rats which were pretreated with cortisone acetate in vivo. Studies with alpha-amanitine and cordycepin--given in vivo--showed, that the synthesis of m -RNA for tryptophan oxygenase after application of 1 mg/kg cortisone acetate lasted for less than 2 h. The results obtained in vitro were very similar to those reported earlier. Maximum activity is obtained in the presence of the substrate L-tryptophan. When adding other amino acids instead of the substrate no effect can be observed. The same is true also for actinomycin D. In the presence of puromycin and cycloheximide the enzyme activity decreases.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0004-4172
pubmed:author
pubmed:issnType
Print
pubmed:volume
29
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1129-32
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1979
pubmed:articleTitle
Influence of L-tryptophan on the activity of tryptophan oxygenase in rat liver slices.
pubmed:publicationType
Journal Article, In Vitro